A0A6J4K6D7 · A0A6J4K6D7_9BACT

Function

function

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site180substrate
Binding site209substrate
Binding site238substrate
Binding site274substrate
Binding site294-296substrate
Binding site335-338substrate
Binding site374substrate
Binding site378Zn2+ (UniProtKB | ChEBI)
Binding site401substrate
Binding site442Zn2+ (UniProtKB | ChEBI)
Binding site522[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site525[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site530[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-carbon lyase activity
Molecular Functionzinc ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomethylpyrimidine synthase
  • EC number
  • Alternative names
    • Hydroxymethylpyrimidine phosphate synthase
      (HMP-P synthase
      ; HMP-phosphate synthase
      ; HMPP synthase
      )
    • Thiamine biosynthesis protein ThiC

Gene names

    • Name
      thiC
    • ORF names
      AVDCRST_MAG68-67

Organism names

Accessions

  • Primary accession
    A0A6J4K6D7

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-82ThiC-associated

Sequence similarities

Belongs to the ThiC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    574
  • Mass (Da)
    64,015
  • Last updated
    2020-10-07 v1
  • Checksum
    E9E33A55B715E728
MTNGERGTRNGERAGDYGDNFPASRKVYVDGRHGVRVPMREIVLSGGEPPLRVYDTSGPLGGDVRRGLEPLRAEWIRARGDVAEAARTYRPLPGAQVVEMPEALHRPTLRGTGCVTQMAYARRGEITAEMEFVALREGMSPEFVRDEVARGRAIIPANINHPELEPMIIGRGFKVKVNANIGNSAVTSSIEEEVEKLRWATLWGADTVMDLSTGKNIHETREWILRNSPVPIGTVPIYQALEKVGGVPEELTWELYRDTLIEQAEQGVDYFTVHAGVLLRYVPMTANRLTGIVSRGGSIIAKWCLAHHRESFLYTHFREICEIMRAYDVSFSLGDGLRPGSIRDANDEAQFAELRTQGELNRIAWEFDVQTMNEGPGHVPMHLIQENMDRQLEWCHEAPFYTLGPLTTDIAPGYDHITSAIGAAQIGWYGTAMLCYVTPKEHLGLPNRDDVKAGVITYKIAAHAADLAKRHPRAQEWDDALSKARFEFRWRDQFNLSLDPVTALSYHDETLPAEGAKIAHFCSMCGPKFCSMKITQDVRDYAAKQAAAEAGMAEKSVEFREKGAEIYLPEPAVP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CADCTW010000007
EMBL· GenBank· DDBJ
CAA9296999.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help