A0A6J3HV87 · A0A6J3HV87_SAPAP
- ProteinUbiquitin carboxyl-terminal hydrolase
- GeneUSP37
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids981 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cysteine-type deubiquitinase activity | |
Biological Process | cell division | |
Biological Process | protein deubiquitination | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Cebinae > Sapajus
Accessions
- Primary accessionA0A6J3HV87
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 131-147 | Polar residues | ||||
Sequence: KEISRQLSYSDNQAPAK | ||||||
Region | 131-165 | Disordered | ||||
Sequence: KEISRQLSYSDNQAPAKRGSLETKDDIPFRKVLGS | ||||||
Region | 188-306 | Disordered | ||||
Sequence: LTSTSTPLRSGLLENRTEKRKRVLSAGPELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEYSPGGTNLDRTNVSSQTPSAKRSLGF | ||||||
Compositional bias | 200-226 | Basic and acidic residues | ||||
Sequence: LENRTEKRKRVLSAGPELNEDYPKEND | ||||||
Compositional bias | 227-303 | Polar residues | ||||
Sequence: SSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEYSPGGTNLDRTNVSSQTPSAKRS | ||||||
Domain | 343-953 | USP | ||||
Sequence: QGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKHSVALSQRLCEMSGSDQQQEDLEKDSKLCRTEPDKSELENSGFDRMSEEELLAAVLEISKREASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHK | ||||||
Region | 670-705 | Disordered | ||||
Sequence: EMSGSDQQQEDLEKDSKLCRTEPDKSELENSGFDRM | ||||||
Compositional bias | 676-705 | Basic and acidic residues | ||||
Sequence: QQQEDLEKDSKLCRTEPDKSELENSGFDRM | ||||||
Region | 721-797 | Disordered | ||||
Sequence: EASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVD | ||||||
Compositional bias | 722-739 | Basic and acidic residues | ||||
Sequence: ASPSLSHEDDDKPTSSPD | ||||||
Compositional bias | 774-791 | Basic and acidic residues | ||||
Sequence: TEITKDCDENKENKTPEG | ||||||
Coiled coil | 799-830 | |||||
Sequence: LQQYDMEREREEQELQQALAQSLQEQEAWEQK |
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length981
- Mass (Da)110,364
- Last updated2020-10-07 v1
- Checksum06FF3C663DFC464E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6J3HVW8 | A0A6J3HVW8_SAPAP | USP37 | 959 | ||
A0A6J3HV91 | A0A6J3HV91_SAPAP | USP37 | 848 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 131-147 | Polar residues | ||||
Sequence: KEISRQLSYSDNQAPAK | ||||||
Compositional bias | 200-226 | Basic and acidic residues | ||||
Sequence: LENRTEKRKRVLSAGPELNEDYPKEND | ||||||
Compositional bias | 227-303 | Polar residues | ||||
Sequence: SSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEYSPGGTNLDRTNVSSQTPSAKRS | ||||||
Compositional bias | 676-705 | Basic and acidic residues | ||||
Sequence: QQQEDLEKDSKLCRTEPDKSELENSGFDRM | ||||||
Compositional bias | 722-739 | Basic and acidic residues | ||||
Sequence: ASPSLSHEDDDKPTSSPD | ||||||
Compositional bias | 774-791 | Basic and acidic residues | ||||
Sequence: TEITKDCDENKENKTPEG |
Keywords
- Technical term