A0A6J3D9E2 · A0A6J3D9E2_AYTFU

Function

function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionJUN kinase activity
Molecular Functionprotein serine kinase activity
Biological Processpositive regulation of apoptotic process
Biological Processprotein phosphorylation
Biological Processresponse to mechanical stimulus
Biological Processrhythmic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Stress-activated protein kinase JNK
  • EC number

Gene names

    • Name
      MAPK8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anatidae > Aythyinae > Aythya

Accessions

  • Primary accession
    A0A6J3D9E2

Proteomes

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain26-321Protein kinase
Region381-427Disordered
Compositional bias385-417Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    427
  • Mass (Da)
    48,296
  • Last updated
    2020-10-07 v1
  • Checksum
    8221740035947B60
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPAPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASAGPLGCCR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6J3DC22A0A6J3DC22_AYTFUMAPK8427
A0A6J3DBL3A0A6J3DBL3_AYTFUMAPK8384

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias385-417Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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