A0A6J2QSV2 · A0A6J2QSV2_COTGO
- Proteincholesterol 7-desaturase
- GeneLOC115016994
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids456 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- cholesterol + H+ + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD+This reaction proceeds in the forward direction.
Cofactor
Pathway
Hormone biosynthesis.
Steroid hormone biosynthesis; dafachronic acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | cholesterol metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecholesterol 7-desaturase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Bovichtidae > Cottoperca
Accessions
- Primary accessionA0A6J2QSV2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 48-68 | Helical | ||||
Sequence: LLARAVVCIITGVSLFVVGWL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 119-223 | Rieske | ||||
Sequence: WYRVLDSHMLPRGEVKSVSVLGEQVAVFRGQDGEAYVVDAYCPHLGANLAVGGRVVGSCIECPFHGWQFRGNDGKCVRIPYAEKVPEFAKVRCWRSCELNGQIMV |
Sequence similarities
Belongs to the cholesterol 7-desaturase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length456
- Mass (Da)51,826
- Last updated2020-10-07 v1
- ChecksumFB64063CB4E024A5
Keywords
- Technical term