A0A6J2ATK2 · AMPQ_ACIJB

Function

function

Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface (By similarity).
Involved in coat pigmentation patterns. During skin development, may be required to establish the periodicity of tabby markings, initiating a pre-pattern at or before hair follicle development (PubMed:22997338).

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

1992100200300400500600700800900
TypeIDPosition(s)Description
Binding site241substrate
Binding site380-384substrate
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417Proton acceptor
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site439Zn2+ (UniProtKB | ChEBI); catalytic
Active site505Proton donor
Site505Transition state stabilizer

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetalloaminopeptidase activity
Molecular Functionpeptide binding
Molecular Functionzinc ion binding
Biological Processpeptide catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminopeptidase Q
  • EC number
  • Alternative names
    • Laeverin
    • Tabulin
    • Transmembrane Aminopeptidase Q

Gene names

    • Name
      LVRN
    • Synonyms
      TAQPEP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Acinonychinae > Acinonyx

Accessions

  • Primary accession
    A0A6J2ATK2

Proteomes

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-13Cytoplasmic
Transmembrane14-34Helical; Signal-anchor for type II membrane protein
Topological domain35-992Extracellular

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, glycosylation.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00004523242-992Aminopeptidase Q
Glycosylation133N-linked (GlcNAc...) asparagine
Glycosylation262N-linked (GlcNAc...) asparagine
Glycosylation289N-linked (GlcNAc...) asparagine
Glycosylation347N-linked (GlcNAc...) asparagine
Glycosylation361N-linked (GlcNAc...) asparagine
Glycosylation489N-linked (GlcNAc...) asparagine
Glycosylation584N-linked (GlcNAc...) asparagine
Glycosylation602N-linked (GlcNAc...) asparagine
Glycosylation609N-linked (GlcNAc...) asparagine
Glycosylation655N-linked (GlcNAc...) asparagine
Glycosylation811N-linked (GlcNAc...) asparagine
Glycosylation850N-linked (GlcNAc...) asparagine
Glycosylation889N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Tissue specificity

Expressed in skin. Expression levels do not differ between dark and light skin areas.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region48-92Disordered

Sequence similarities

Belongs to the peptidase M1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    992
  • Mass (Da)
    113,497
  • Last updated
    2020-10-07 v1
  • Checksum
    49274CDC4859717B
MGPPSSSGFYVSRAVALLLAALAAALLLALAVLAALYGRCARVQPSDLHHGGVPDAASSPRGTQEEQLPTWPPRPTREPAGTATPGHWRPPGPWDQLRLPPWLVPLHYELELWPRLRPNEFQSPTLSFTGRVNITVRCTAATARLLLHSLFLDCESAEVRGPLSSGPRDGAVGRVPVDDVWFAFDMQYMVLELGATLQPGSRYELQLSFSGLVYRDLREGLFFSIYTDQGERRALLASQMEPTFARSVFPCFDEPALKATFNITIIHHPSYGALSNMPKLGQSEKRDVNGSVWTITTFSTTPHMPTYLVALAICDYDHVSRTERGQEIRIWARKDAIANGNAAFALNITGPIFSFLEDLFNISYPLPKTDIIALPTFDNSAMENWGLLIFDESLLLMQPNDQVTDKKAVISFILSHEIGHQWFGNLVTMNWWNDIWLKEGFASYFEFGVINYFNPKFRRNEVFFSNILHHVLSEDHALVSRAVSLKVENFTETSEINELFDLFTYNKGASLARMLSSFLNENVFISALKSYLKTFSYSTAEQDDLWRHFQMVVDDQSKILLPAPVKSIMDRWTHQSGFPVITLNVSTGAMKQEPFYLGKVKNQTLLTHNDTWIVPILWIKNGITQSLVWLDKSSKIFPEMQVSDSDHDWVILNLNMTGYYRVNYDKVGWKKLKQQLEKDPKAIPVIHRLQMIDDAFSLSKNNYVEIETALDLTKYLAEEDEIIVWYAVLVNLVTKDLVFDVNNYDMYPLLKKYLLKRLISIWNMYSTVIRENVAALQDDYLALVALEKLFETACWLGLEDCLQLSRELFKNWTNHPENEIPYPIKSVVLCYGVAFGSDEEWDFLLNMYSNKTKEEERIQLTYAMSCSKDPWILHRYLEYAVTAAPFTFNETNIMEVVAESEVGRYIVKDFLINNWQAVSERYGTQSLVNLMYIIGRTISTDLQITELQQFFSNMLEEHQKLTVRAKLQTIKNKNLGNKKLNARMTAWLRKNT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8N3GNP1A0A8N3GNP1_ACIJBLVRN992

Polymorphism

A frameshift variant at position 997 (p.Asn977LysfsTer110) has been shown to cosegregate with the king coat pattern, a rare phenotype in which spots coalesce into blotches and stripes. This polymorphism was not detected in almost 220 spotted cheetahs.

Keywords

Similar Proteins

Disclaimer

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