A0A6J1BVV4 · A0A6J1BVV4_MOMCH
- ProteinGlutathione hydrolase
- GeneLOC111005973
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids570 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 97 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 366 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 384-386 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TVN | ||||||
Binding site | 408 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 436-437 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 458 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Cucurbitales > Cucurbitaceae > Momordiceae > Momordica
Accessions
- Primary accessionA0A6J1BVV4
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MLMRWLIIVLVSTALLPPTFI | ||||||
Chain | PRO_5042388576 | 22-570 | Glutathione hydrolase | |||
Sequence: ARPEVTVASHGAVAADDGRCSRIGMEVLREGGHAVDASVAAALCLGVVSPASSGIGGGAFMLIRSADGHSQALDMRETAPFLASENMYAGNAASKAAGALSIGVPGELAGLHEAWKQHGRLSWARLVQPAERLARLGFKISPYLHMQMVRTEPGILGDEGLRNLFTSGGKLLKPGDVVRNKKLAKTLRTISRFGVKAFYNGSIGINLIRDIRKLGGILSMKDLQSYQVKLRVPILARTMGLELITMPPPSGGSGVILMLNILAQYKPPSGLSGPLGIHREIEALKHVIAVRTNLGDPSFFNVSEVLSNMLSPKFAQQLKKTIYDNRTFDPSHYGGRWNPINDHGTSHLSIVDAERNAVSMTTTVNSYFGAHILSPSTGIVLNNEMDDFSVPANVSANKLPPAPANFIRPGKRPLSSMSPTIVLKDGKLKGVVGASGGGFIIAGTAEVLLNHFAKGMDPLSSVMAPRVYHPLIPNVVNYENWTTVLGDHFEVPAKTRAVLAKKGHVLEGLAGGTICQFIVQDYSSLGKGVGVGKLVAVSDPRKGGVPSGF |
Structure
Sequence
- Sequence statusComplete
- Length570
- Mass (Da)60,583
- Last updated2020-10-07 v1
- Checksum7603EA16F89EE211
Keywords
- Technical term