A0A6J1ASV4 · A0A6J1ASV4_9ROSI

  • Protein
    Inosine triphosphate pyrophosphatase
  • Gene
    LOC110420992
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site18-23ITP (UniProtKB | ChEBI)
Binding site46Mg2+ (UniProtKB | ChEBI)
Binding site58ITP (UniProtKB | ChEBI)
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site74-75ITP (UniProtKB | ChEBI)
Binding site150-153ITP (UniProtKB | ChEBI)
Binding site173ITP (UniProtKB | ChEBI)
Binding site178-179ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      LOC110420992

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Byttnerioideae > Herrania

Accessions

  • Primary accession
    A0A6J1ASV4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,380
  • Last updated
    2020-10-07 v1
  • Checksum
    815BBD602500798C
MEAAGRAVLVSRPVTFVTGNAKKLEEVKTILGQSIPFQSLKLDLPELQGEPEEISKEKARLAAVQVNGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNLLMAYEDKSAYALCAFSFALGPDVEPITFLGKTPGKIVPARGPNDFGWDPIFQPDGYDQTYAEMPKEEKNKISHRYRALAMVKSHFAEAGYSFSTPSKE

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6J1AUH1A0A6J1AUH1_9ROSILOC110420992170

Keywords

Sequence databases

Similar Proteins

Disclaimer

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