A0A6J0T0A8 · A0A6J0T0A8_9SAUR

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentsite of double-strand break
Cellular Componentubiquitin ligase complex
Molecular Functionchromatin binding
Molecular Functionhistone binding
Molecular Functionmetal ion binding
Molecular Functionubiquitin binding
Molecular Functionubiquitin protein ligase activity
Biological Processchromatin organization
Biological Processdouble-strand break repair
Biological Processpositive regulation of DNA repair
Biological Processprotein K48-linked ubiquitination
Biological Processresponse to ionizing radiation
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase CHFR
  • EC number

Gene names

    • Name
      RNF8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Iguania > Acrodonta > Agamidae > Amphibolurinae > Pogona

Accessions

  • Primary accession
    A0A6J0T0A8

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain42-96FHA
Region144-223Disordered
Compositional bias148-165Basic and acidic residues
Coiled coil255-307
Coiled coil357-405
Domain409-447RING-type

Sequence similarities

Belongs to the CHFR family.
Belongs to the RNF8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    57,412
  • Last updated
    2020-10-07 v1
  • Checksum
    478B3C8F72A2DDA3
MAERFGGAGRVSLPSEGSDVIWCLVRVGMKGEWLLLEDGSEVTIGRGAGVTYQLMSKSCPLMISRNHCVFKQNTDGQWTVTDNKSLNGVWLNCERIDTSRAYSLQEGDIIQLGVPLKHRETAEYEYRLIKEEWKKVSPFLAQKNDQLTEQTKDMRAKRKISLEESEASGAEGPSNFRSKRDRVSSDNGSLAKSEGGRTELSKQPVENMDIVLLPPKPSKKEKKKNHCSTVQLEHGSCFISKDQKAPSLAQSWNGLEQIMKTLADMTKLKTKMQEKQTAVLNVRQKNKKCAPKEIQVLEQELQDLQDQLCTEQEHQQQRVQQLEKTFYEELEGAKEEHVELKLKEQLAQVLAQHHALMEELSRSKKDFEEIIKAKDRELKETKEEKEKARAQKEEALSQMNDVLENELQCTICSEHFIEAVTLNCAHSFCSYCISEWMKRRLECPICRRIIISKTRSLVLDNCIDRMVENLDDETKRHRLALIQERKGEREAGCSGEPSIRQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6J0SWH9A0A6J0SWH9_9SAURRNF8553

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias148-165Basic and acidic residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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