A0A6J0ALG6 · A0A6J0ALG6_VICPA
- ProteinPhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- GeneMTMR2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids571 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphateThis reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 258-261 | substrate | |||
Binding site | 283-284 | substrate | |||
Active site | 345 | Phosphocysteine intermediate | |||
Binding site | 345-351 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Tylopoda > Camelidae > Vicugna
Accessions
- Primary accessionA0A6J0ALG6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 133-508 | Myotubularin phosphatase | |||
Domain | 314-361 | Tyrosine specific protein phosphatases | |||
Region | 543-571 | Disordered | |||
Compositional bias | 546-571 | Polar residues | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length571
- Mass (Da)65,858
- Last updated2020-10-07 v1
- MD5 Checksum8A15DD704637793C0BCFB8E043137149
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6J3ABS8 | A0A6J3ABS8_VICPA | MTMR2 | 600 | ||
A0A6J3AA71 | A0A6J3AA71_VICPA | MTMR2 | 527 | ||
A0A6J0AMP9 | A0A6J0AMP9_VICPA | MTMR2 | 592 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 546-571 | Polar residues | |||
Keywords
- Technical term