A0A6I8SVS9 · A0A6I8SVS9_XENTR

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site131substrate
Active site218Proton acceptor
Active site396For cyclooxygenase activity
Binding site399Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Molecular Functiondioxygenase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxidase activity
Molecular Functionprostaglandin-endoperoxide synthase activity
Biological Processprostaglandin biosynthetic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin G/H synthase 1
  • EC number
  • Alternative names
    • Cyclooxygenase-1
    • Prostaglandin H2 synthase 1
    • Prostaglandin-endoperoxide synthase 1

Gene names

    • Name
      ptgs1
    • Synonyms
      cox1

Organism names

Accessions

  • Primary accession
    A0A6I8SVS9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_504272917019-607Prostaglandin G/H synthase 1

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-81EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    69,992
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    31A1B51B259A3918B0D8B18E1B1F0CFA
MAGLCLTVLFVIVTTSYSLEVSDKETNLPSIESRFPYSLSMLTVNPCCYYPCQHKGVCVRFEMDKYLCDCTRTGYYGTNCTIPEWWTKFREFLRPSPAFYHYILTRFKWFWDIINSTFIRDVIVRLVLTVRSNLIPSPPTYNSAYGYISWEAYSNVSYFTRVLPPVPDDCPTPMGTKGKMELPDASLLVETFLKREKFIPDPQGTNLLFAFFAQHFTHQFFKTYGRMGRGFIKGFGHGVDLSHIYGDSLERQHMLRLFTDGKLKYQIINGDIYPPTVVEAPVFMIYPDNVPKEKQFAVGQEVFGLLPGLMMYATLWLREHNRVCDILKKEHPTWDDEQLFQTTRLILIGETIKIVIEDYVQHLSGYYLKLKFDPELLFGVQFQYRNRIAVEFNQLYHWHPLIPEKFQILEDEYSHSRFLYNTSILLDYGVEALVESFTKQIAGKIGGGKNHHPGLLKVAAGVIEESRKLRLQPFNEYRKRFGLKAYKSFKDLTGEEIMSAQLEELYGDIDALEFYLGLLLEKSNPNSIFGESMVEIGAPFSLKGLMGNPICSPEYWKPSTFGGETGFNIVKTATIQKLVCLNVKQCPFVAFHVPDDVLPKLKKSDEL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F6PNE5F6PNE5_XENTRptgs1588

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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