A0A6I8SVS9 · A0A6I8SVS9_XENTR
- ProteinProstaglandin G/H synthase 1
- Geneptgs1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids607 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 131 | substrate | |||
Active site | 218 | Proton acceptor | |||
Active site | 396 | For cyclooxygenase activity | |||
Binding site | 399 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Molecular Function | dioxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | peroxidase activity | |
Molecular Function | prostaglandin-endoperoxide synthase activity | |
Biological Process | prostaglandin biosynthetic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin G/H synthase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8SVS9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5042729170 | 19-607 | Prostaglandin G/H synthase 1 | ||
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)69,992
- Last updated2021-06-02 v2
- MD5 Checksum31A1B51B259A3918B0D8B18E1B1F0CFA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F6PNE5 | F6PNE5_XENTR | ptgs1 | 588 |
Keywords
- Technical term