A0A6I8RY16 · A0A6I8RY16_XENTR
- ProteinPhosphodiesterase
- Genepde4d
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids689 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 347 | Proton donor | |||
Binding site | 347-351 | AMP (UniProtKB | ChEBI) | |||
Binding site | 351 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 387 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 388 | AMP (UniProtKB | ChEBI) | |||
Binding site | 388 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 388 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 505 | AMP (UniProtKB | ChEBI) | |||
Binding site | 505 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 556 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | cAMP catabolic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8RY16
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 228-248 | Disordered | |||
Compositional bias | 230-247 | Basic and acidic residues | |||
Domain | 271-600 | PDEase | |||
Region | 595-689 | Disordered | |||
Compositional bias | 610-625 | Basic and acidic residues | |||
Compositional bias | 643-662 | Polar residues | |||
Compositional bias | 663-677 | Acidic residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length689
- Mass (Da)78,292
- Last updated2020-08-12 v1
- MD5 Checksum4F0B748628C700900F2FBD8CABF0F6CE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 230-247 | Basic and acidic residues | |||
Compositional bias | 610-625 | Basic and acidic residues | |||
Compositional bias | 643-662 | Polar residues | |||
Compositional bias | 663-677 | Acidic residues | |||