A0A6I8RY16 · A0A6I8RY16_XENTR

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Features

Showing features for active site, binding site.

168950100150200250300350400450500550600650
Type
IDPosition(s)Description
Active site347Proton donor
Binding site347-351AMP (UniProtKB | ChEBI)
Binding site351Zn2+ 1 (UniProtKB | ChEBI)
Binding site387Zn2+ 1 (UniProtKB | ChEBI)
Binding site388AMP (UniProtKB | ChEBI)
Binding site388Zn2+ 2 (UniProtKB | ChEBI)
Binding site388Zn2+ 1 (UniProtKB | ChEBI)
Binding site505AMP (UniProtKB | ChEBI)
Binding site505Zn2+ 1 (UniProtKB | ChEBI)
Binding site556AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological ProcesscAMP catabolic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      pde4d

Organism names

Accessions

  • Primary accession
    A0A6I8RY16

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region228-248Disordered
Compositional bias230-247Basic and acidic residues
Domain271-600PDEase
Region595-689Disordered
Compositional bias610-625Basic and acidic residues
Compositional bias643-662Polar residues
Compositional bias663-677Acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    689
  • Mass (Da)
    78,292
  • Last updated
    2020-08-12 v1
  • MD5 Checksum
    4F0B748628C700900F2FBD8CABF0F6CE
MFPPLVRRYMQAKRWQYGNYHPCVDFSFFSPSASCCSFDVDNGTTSGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYELSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSTMCNQPSINKATIPEEAYQKLAGETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEMPSPAQKEKEKKKRPMSQISGVKKLMHSSSLTNSNIPRFGVKSENEECLAKELEDVNKWGLNIFKVAEFSGNRPLTVVMHTIFQEREMLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVAQSTHVLLSSPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQLLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLPLYRHWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDEQEEGKQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDDQVDEEESQLEPNSIEQAHSPDT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias230-247Basic and acidic residues
Compositional bias610-625Basic and acidic residues
Compositional bias643-662Polar residues
Compositional bias663-677Acidic residues

Genome annotation databases

Similar Proteins

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