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A0A6I8RR90 · A0A6I8RR90_XENTR

Function

function

Proteolytically removes the C-terminal three residues of farnesylated proteins.

Catalytic activity

  • Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.
    EC:3.4.24.84 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

145850100150200250300350400450
Type
IDPosition(s)Description
Binding site318Zn2+ (UniProtKB | ChEBI); catalytic
Active site319
Binding site322Zn2+ (UniProtKB | ChEBI); catalytic
Binding site398Zn2+ (UniProtKB | ChEBI); catalytic
Active site402Proton donor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological ProcessCAAX-box protein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CAAX prenyl protease
  • EC number

Gene names

    • Name
      zmpste24

Organism names

Accessions

  • Primary accession
    A0A6I8RR90

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-89Helical
Transmembrane110-131Helical
Transmembrane158-176Helical
Transmembrane183-203Helical
Transmembrane332-350Helical
Transmembrane357-379Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503150971519-458CAAX prenyl protease

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-212CAAX prenyl protease 1 N-terminal
Domain216-453Peptidase M48

Sequence similarities

Belongs to the peptidase M48A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    52,320
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    BCDBED2E6F2F8971B9B2ED437A3CB398
MASLLVALLITLLVICQGQHKEGILKCKRKIYRTTTHVPAELGNIMDAETFEKSRLYQLDKSTFSFWSGLYSEAEGTLILLLGGIPFLWNIAEQMLYRAGFSAEYEIIHSLVFLLLATLFSAFTGLPWSLYNTFVIEERHGFNQQTLGFFFKDAVKKFLVTQCILLPVASLLLYIIKMGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGDLKESIENMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEDYSPLNKEGTEDTSGNENTELKAKVKQNLNKKQGCNNQEVLAVLGHELGHWKLGHTVKNIVISQVNSFLCFFLFAVLIGRKELFAAFGFYNTQPTLIGLMIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFARNLGKAKDLYSALIKLNKDNLGFPVSDWVFSMWHYSHPPLLERLQALKVDKQN

Genome annotation databases

Similar Proteins

Disclaimer

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