A0A6I8RMG7 · CREL1_XENTR
- ProteinProtein disulfide isomerase CRELD1
- Genecreld1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids410 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Protein disulfide isomerase (By similarity).
Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | isomerase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein disulfide isomerase CRELD1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8RMG7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-352 | Extracellular | ||||
Sequence: QLCQTCQNLVTNVLKGIEKTAGLNFGGGNTAWEEEKLSKYEISETRLLEVIETACDKSDFDCNKMLEQNEEHMESWWFKKQKEQPDLFQWLCMDTLRLCCPKGRFGADCLSCPGGTEKPCSGNGQCNGDGTRFGTGVCDCYTSYGGPVCMDCALGYYEQARNESHLVCSECYRACSKCIGPGDDQCVLCKRGWLLHDGKCIDIDECGTEKDHCKSNQFCFNTDGSYECRECDKSCIGCMGGGPARCKKCNKGYYRDGVKCLDVDECDSELPKCKGSHEECVNTEGSFTCVCEKDYSRIDGMCRPDSYDSNAEKGLFDDITDDE | ||||||
Transmembrane | 353-373 | Helical | ||||
Sequence: VVVLQQMFFGVVICALATLAA | ||||||
Topological domain | 374 | Cytoplasmic | ||||
Sequence: K | ||||||
Transmembrane | 375-395 | Helical | ||||
Sequence: GDMVFTAIFIGAVAAMAGYWL | ||||||
Topological domain | 396-410 | Extracellular | ||||
Sequence: SEKGDRALDSFMKGR |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
About half of the knockdown tadpoles exhibit severe defects of either early gastrulation disruption or edema and late embryonic lethality. Some also have tail defects. Surviving tadpoles show more robust seizure behaviors than wild-type in response to pilocarpine treatment.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MGMSRRMFLTVYGSLWLLLLLSRPGVSKP | ||||||
Chain | PRO_5041613138 | 30-410 | Protein disulfide isomerase CRELD1 | |||
Sequence: QLCQTCQNLVTNVLKGIEKTAGLNFGGGNTAWEEEKLSKYEISETRLLEVIETACDKSDFDCNKMLEQNEEHMESWWFKKQKEQPDLFQWLCMDTLRLCCPKGRFGADCLSCPGGTEKPCSGNGQCNGDGTRFGTGVCDCYTSYGGPVCMDCALGYYEQARNESHLVCSECYRACSKCIGPGDDQCVLCKRGWLLHDGKCIDIDECGTEKDHCKSNQFCFNTDGSYECRECDKSCIGCMGGGPARCKKCNKGYYRDGVKCLDVDECDSELPKCKGSHEECVNTEGSFTCVCEKDYSRIDGMCRPDSYDSNAEKGLFDDITDDEVVVLQQMFFGVVICALATLAAKGDMVFTAIFIGAVAAMAGYWLSEKGDRALDSFMKGR | ||||||
Disulfide bond | 32↔35 | Redox-active | ||||
Sequence: CQTC | ||||||
Disulfide bond | 141↔155 | |||||
Sequence: CPGGTEKPCSGNGQC | ||||||
Disulfide bond | 149↔167 | |||||
Sequence: CSGNGQCNGDGTRFGTGVC | ||||||
Disulfide bond | 169↔178 | |||||
Sequence: CYTSYGGPVC | ||||||
Disulfide bond | 264↔267 | Redox-active | ||||
Sequence: CIGC | ||||||
Disulfide bond | 295↔309 | |||||
Sequence: CDSELPKCKGSHEEC | ||||||
Disulfide bond | 302↔318 | |||||
Sequence: CKGSHEECVNTEGSFTC | ||||||
Disulfide bond | 320↔331 | |||||
Sequence: CEKDYSRIDGMC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 32-35 | CXXC | ||||
Sequence: CQTC | ||||||
Domain | 139-179 | EGF-like 1 | ||||
Sequence: LSCPGGTEKPCSGNGQCNGDGTRFGTGVCDCYTSYGGPVCM | ||||||
Repeat | 194-243 | FU 1 | ||||
Sequence: HLVCSECYRACSKCIGPGDDQCVLCKRGWLLHDGKCIDIDECGTEKDHCK | ||||||
Repeat | 254-301 | FU 2 | ||||
Sequence: SYECRECDKSCIGCMGGGPARCKKCNKGYYRDGVKCLDVDECDSELPK | ||||||
Motif | 264-267 | CXXC | ||||
Sequence: CIGC | ||||||
Domain | 291-332 | EGF-like 2; calcium-binding | ||||
Sequence: DVDECDSELPKCKGSHEECVNTEGSFTCVCEKDYSRIDGMCR |
Sequence similarities
Belongs to the CRELD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length410
- Mass (Da)45,448
- Last updated2020-08-12 v1
- ChecksumFF004C6BD1A5C349
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAMC04000004 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |