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A0A6I8R1Z8 · A0A6I8R1Z8_XENTR

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for site, binding site.

1884100200300400500600700800
Type
IDPosition(s)Description
Site475Interaction with the cone snail toxin Con-ikot-ikot
Binding site500L-glutamate (UniProtKB | ChEBI)
Binding site502L-glutamate (UniProtKB | ChEBI)
Binding site507L-glutamate (UniProtKB | ChEBI)
Site655Crucial to convey clamshell closure to channel opening
Binding site676L-glutamate (UniProtKB | ChEBI)
Binding site677L-glutamate (UniProtKB | ChEBI)
Site682Interaction with the cone snail toxin Con-ikot-ikot
Binding site727L-glutamate (UniProtKB | ChEBI)
Site774Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular Componentpostsynaptic membrane
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functionsignaling receptor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      gria4
    • Synonyms
      glur4

Organism names

Accessions

  • Primary accession
    A0A6I8R1Z8

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Postsynaptic cell membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane543-565Helical
Transmembrane626-648Helical
Transmembrane816-838Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_504265608722-884Glutamate receptor
Disulfide bond84↔331
Disulfide bond740↔795

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain416-791Ionotropic glutamate receptor C-terminal
Domain426-491Ionotropic glutamate receptor L-glutamate and glycine-binding

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    884
  • Mass (Da)
    99,474
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    7D531F39D679DABAA67E0BF405A80E4A
MRMICQQMVLFFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNESEALFNLVPHVDNIETSNSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYGWNHYVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQENKFVIDCEVERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLDRFMHGGANVTGFQLVDFNTPIVTELMQRWKTLDQREYPGSESPPKYTSALTYDGVLVMAEAFRILRRQKIDLSRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVLELKSNGLRKIGYWNDMDKLVLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYKKNHELLEGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFKRSKIAVYEKMWTYMKSAEPSVFTKTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKSAQNFKTTSSQNTQNLATYREGYNVYGTESVKI

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J1J385A0A8J1J385_XENTRgria4902
F6Z2A1F6Z2A1_XENTRgria4876
A0A8J1J485A0A8J1J485_XENTRgria4902
F6T3C9F6T3C9_XENTRgria4884
A0A6I8Q867A0A6I8Q867_XENTRgria4814
A4IIS9A4IIS9_XENTRgria4433

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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