A0A6I8R1Z8 · A0A6I8R1Z8_XENTR
- ProteinGlutamate receptor
- Genegria4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids884 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 475 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 500 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 502 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 507 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 655 | Crucial to convey clamshell closure to channel opening | |||
Binding site | 676 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 677 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 682 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 727 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 774 | Interaction with the cone snail toxin Con-ikot-ikot | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | postsynaptic membrane | |
Molecular Function | ligand-gated monoatomic ion channel activity | |
Molecular Function | signaling receptor activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8R1Z8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 543-565 | Helical | |||
Transmembrane | 626-648 | Helical | |||
Transmembrane | 816-838 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5042656087 | 22-884 | Glutamate receptor | ||
Disulfide bond | 84↔331 | ||||
Disulfide bond | 740↔795 | ||||
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 416-791 | Ionotropic glutamate receptor C-terminal | |||
Domain | 426-491 | Ionotropic glutamate receptor L-glutamate and glycine-binding | |||
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length884
- Mass (Da)99,474
- Last updated2021-06-02 v2
- MD5 Checksum7D531F39D679DABAA67E0BF405A80E4A
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J1J385 | A0A8J1J385_XENTR | gria4 | 902 | ||
F6Z2A1 | F6Z2A1_XENTR | gria4 | 876 | ||
A0A8J1J485 | A0A8J1J485_XENTR | gria4 | 902 | ||
F6T3C9 | F6T3C9_XENTR | gria4 | 884 | ||
A0A6I8Q867 | A0A6I8Q867_XENTR | gria4 | 814 | ||
A4IIS9 | A4IIS9_XENTR | gria4 | 433 |
Keywords
- Technical term