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A0A6I8QGZ3 · A0A6I8QGZ3_XENTR

Function

Catalytic activity

  • Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
    EC:3.1.6.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

152050100150200250300350400450500
Type
IDPosition(s)Description
Binding site36Ca2+ (UniProtKB | ChEBI)
Binding site37Ca2+ (UniProtKB | ChEBI)
Active site76Nucleophile
Binding site76Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Active site139
Binding site286Ca2+ (UniProtKB | ChEBI)
Binding site287Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentlysosome
Molecular Functionmetal ion binding
Molecular FunctionN-acetylgalactosamine-6-sulfatase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylgalactosamine-6-sulfatase
  • EC number
  • Alternative names
    • Chondroitinsulfatase
    • Galactose-6-sulfate sulfatase
    • N-acetylgalactosamine-6-sulfate sulfatase

Gene names

    • Name
      galns

Organism names

Accessions

  • Primary accession
    A0A6I8QGZ3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, modified residue, glycosylation.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_504272872222-520N-acetylgalactosamine-6-sulfatase
Modified residue763-oxoalanine (Cys)
Glycosylation201N-linked (GlcNAc...) asparagine

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain28-353Sulfatase N-terminal

Sequence similarities

Belongs to the sulfatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    58,195
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    32BAE9794EE866A17946143A448C6770
MALYIMYALALGFLNPVLVLGGMNGTRPNILLLLMDDMGWGDLGVFGEPSRETPNLDKMASEGMLFPNFYTANPLCSPSRAALLTGRLPIRNGFYTTNSHARNAYTPQEIMGGIPDSEVLFPELLKKAGYVNKIIGKWHLGHRPSYHPLRRGFDEWFGSPNCHFGPYDNKQRPNIPVYRDWDMVGRYYEDFNIDHKTGESNLTQIYLQEALEFINRQAGDQQPFFLYWSIDATHAPVYASRPFLGTSRRGLYGDAVREIDFSIGKILGLLNQKDIIKDTFVFFTSDNGAALISAPMQGGSNGPFLCGKQTTFEGGMRVPGIAWWPGHVAPGQVSYQLGSIMDLFTTSLSLAGVEIPKDRAIDGIDLSPVILESEETERPIFYYRGNELMAVRLGQHKAHYWTWSNSWEELSQGINFCPGQNITGVTTHVQVEHSINPLLFHLGRDPGEKYSISVLSTEYEAALSRISPVVQQHRNSMVPGEPQLNVCDLAVMNWSPPGCEKLGKCLTPPQSNPWKCVWPH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J0SLE9A0A8J0SLE9_XENTRgalns483

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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