A0A6I8QC27 · A0A6I8QC27_XENTR

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Features

Showing features for active site, binding site.

1755100200300400500600700
Type
IDPosition(s)Description
Active site413Proton donor
Binding site413-417AMP (UniProtKB | ChEBI)
Binding site417Zn2+ 1 (UniProtKB | ChEBI)
Binding site453Zn2+ 1 (UniProtKB | ChEBI)
Binding site454AMP (UniProtKB | ChEBI)
Binding site454Zn2+ 2 (UniProtKB | ChEBI)
Binding site454Zn2+ 1 (UniProtKB | ChEBI)
Binding site571AMP (UniProtKB | ChEBI)
Binding site571Zn2+ 1 (UniProtKB | ChEBI)
Binding site622AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological ProcesscAMP catabolic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      pde4d

Organism names

Accessions

  • Primary accession
    A0A6I8QC27

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region294-314Disordered
Compositional bias296-313Basic and acidic residues
Domain337-666PDEase
Region661-755Disordered
Compositional bias676-691Basic and acidic residues
Compositional bias709-728Polar residues
Compositional bias729-743Acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    755
  • Mass (Da)
    85,535
  • Last updated
    2021-06-02 v2
  • MD5 Checksum
    8FE1C97CA3CD207EF8AFB0FB7184C660
MEETSVATCTAEMAQQVAASSDTLAVPEVDNPHCHNNAWLNEDLVNTLRENLLQHDRCKVPRKPISPRLSPVISPRNSPRLLRRMLLNSNIPKQRRFTVAHTCFDVDNGTTSGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYELSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSTMCNQPSINKATIPEEAYQKLAGETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEMPSPAQKEKEKKKRPMSQISGVKKLMHSSSLTNSNIPRFGVKSENEECLAKELEDVNKWGLNIFKVAEFSGNRPLTVVMHTIFQEREMLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVAQSTHVLLSSPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQLLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLPLYRHWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDEQEEGKQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDDQVDEEESQLEPNSIEQAHSPDT

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6I8RBV6A0A6I8RBV6_XENTRpde4d912
A0A6I8QNE7A0A6I8QNE7_XENTRpde4d697
A0A6I8SSN3A0A6I8SSN3_XENTRpde4d513
A0A8J0QYW5A0A8J0QYW5_XENTRpde4d674
A0A6I8QGG9A0A6I8QGG9_XENTRpde4d668

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias296-313Basic and acidic residues
Compositional bias676-691Basic and acidic residues
Compositional bias709-728Polar residues
Compositional bias729-743Acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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