A0A6I8QC27 · A0A6I8QC27_XENTR
- ProteinPhosphodiesterase
- Genepde4d
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids755 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 413 | Proton donor | |||
Binding site | 413-417 | AMP (UniProtKB | ChEBI) | |||
Binding site | 417 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 453 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 454 | AMP (UniProtKB | ChEBI) | |||
Binding site | 454 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 454 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 571 | AMP (UniProtKB | ChEBI) | |||
Binding site | 571 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 622 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | cAMP catabolic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8QC27
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 294-314 | Disordered | |||
Compositional bias | 296-313 | Basic and acidic residues | |||
Domain | 337-666 | PDEase | |||
Region | 661-755 | Disordered | |||
Compositional bias | 676-691 | Basic and acidic residues | |||
Compositional bias | 709-728 | Polar residues | |||
Compositional bias | 729-743 | Acidic residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length755
- Mass (Da)85,535
- Last updated2021-06-02 v2
- MD5 Checksum8FE1C97CA3CD207EF8AFB0FB7184C660
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8RBV6 | A0A6I8RBV6_XENTR | pde4d | 912 | ||
A0A6I8QNE7 | A0A6I8QNE7_XENTR | pde4d | 697 | ||
A0A6I8SSN3 | A0A6I8SSN3_XENTR | pde4d | 513 | ||
A0A8J0QYW5 | A0A8J0QYW5_XENTR | pde4d | 674 | ||
A0A6I8QGG9 | A0A6I8QGG9_XENTR | pde4d | 668 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 296-313 | Basic and acidic residues | |||
Compositional bias | 676-691 | Basic and acidic residues | |||
Compositional bias | 709-728 | Polar residues | |||
Compositional bias | 729-743 | Acidic residues | |||
Keywords
- Technical term