A0A6I8Q741 · A0A6I8Q741_XENTR
- ProteinPeptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
- Genengly1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids635 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
Catalytic activity
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity | |
Biological Process | glycoprotein catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8Q741
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 99-135 | Disordered | |||
Compositional bias | 103-118 | Polar residues | |||
Compositional bias | 119-135 | Pro residues | |||
Domain | 435-635 | PAW | |||
Sequence similarities
Belongs to the transglutaminase-like superfamily. PNGase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length635
- Mass (Da)72,511
- Last updated2021-06-02 v2
- ChecksumF4E278BF2DAFA6D1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 103-118 | Polar residues | |||
Compositional bias | 119-135 | Pro residues | |||
Keywords
- Technical term