A0A6I8PYZ5 · A0A6I8PYZ5_XENTR
- ProteinTyrosine-protein kinase receptor
- Genentrk2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids810 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 504 | Interaction with SHC1 | |||
Binding site | 532-540 | ATP (UniProtKB | ChEBI) | |||
Binding site | 560 | ATP (UniProtKB | ChEBI) | |||
Active site | 664 | Proton acceptor | |||
Site | 805 | Interaction with PLCG1 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | nervous system development | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8PYZ5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 419-442 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-31 | ||||
Chain | PRO_5042728599 | 32-810 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 196-281 | Ig-like | |||
Region | 386-412 | Disordered | |||
Compositional bias | 390-412 | Polar residues | |||
Region | 463-486 | Disordered | |||
Domain | 526-795 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length810
- Mass (Da)90,927
- Last updated2021-06-02 v2
- ChecksumBC0F3D754DBEA5C4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q08D53 | Q08D53_XENTR | ntrk2 | 821 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 390-412 | Polar residues | |||
Keywords
- Technical term