A0A6I8PYZ5 · A0A6I8PYZ5_XENTR

Function

Catalytic activity

Features

Showing features for site, binding site, active site.

1810100200300400500600700800
Type
IDPosition(s)Description
Site504Interaction with SHC1
Binding site532-540ATP (UniProtKB | ChEBI)
Binding site560ATP (UniProtKB | ChEBI)
Active site664Proton acceptor
Site805Interaction with PLCG1

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological Processcell differentiation
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processnervous system development
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor
  • EC number

Gene names

    • Name
      ntrk2
    • Synonyms
      gp145-trkb
      , ntrk2-a
      , ntrk2-b
      , trkb
      , xtrkb

Organism names

Accessions

  • Primary accession
    A0A6I8PYZ5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane419-442Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-31
ChainPRO_504272859932-810Tyrosine-protein kinase receptor

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain196-281Ig-like
Region386-412Disordered
Compositional bias390-412Polar residues
Region463-486Disordered
Domain526-795Protein kinase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    810
  • Mass (Da)
    90,927
  • Last updated
    2021-06-02 v2
  • Checksum
    BC0F3D754DBEA5C4
MRLWKGSHGPDLTQVCGALWILLALVWRGLACPQYCSCNSTRIWCTLEGKGIVAFPVLEDSALAENITDIYIANQRSLASINDDDVKIYTGLRNLTVVDSGLQIVSRQAFSKNPKLTYINFSKNKLTSLPKKLFRHLTLSQLFLGGNPFQCSCDLMWVKVLLETNSLNQNQNIYCFNDNKKKIPLFTMHIPNCGLPIVNVSTLNITVLEGNETTLFCDANGLPDPNVSWDISQIISKSLKETTKRPALLTLKNVTSMDNKRVIVCVAENSVGEDQVSVELNVHFPPVITFIDLPTLDHHWCIPFSVRGNPKPTLQWFHEGSMLSETDFIWSKIHETSNNTSEHHGCLQLDSPTHLNNGFYTLRAENKYGRDERSISALFMERPDDDYETTSNDIGGTSTDIGTGVTSTDVSKEGNEDSITVYVVVGIAALVCTGLVIMLIILKFGRHSKFGLKGPSSVISNDDDSASPLHHISNGSNTPSSSEGGPDTVIIGMTKIPVIENPQYFGITNSHLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLYPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQNLSKASPVYLDILG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q08D53Q08D53_XENTRntrk2821

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias390-412Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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