A0A6I8PS11 · A0A6I8PS11_XENTR

Function

function

Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase
  • EC number

Gene names

    • Name
      fmo1

Organism names

Accessions

  • Primary accession
    A0A6I8PS11

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the FMO family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    59,738
  • Last updated
    2021-06-02 v2
  • Checksum
    E88841623601C3CE
MVKRVAIVGAGCSGLTAIKCCLEEGLEPTCFERSEDIGGLWRFTNNTEEGRGSIYKSVVTNTSKEMMCFSDFPMPEEFPTYLHHSKVLEYLHLYVEHFSLIKYIHFQTEVCSVRKHPDFNSTGLWDVVTQKQGEKTVAIFDAVLICNGHFTDPCLPFECFPGINNFKGSIIHSRTYKTPDSYNGKTVLVVGIGNSAADLAVELAHIAKQVFLSTREGSWVLSRISHNGFPVDMVLSRRFTLLGVHLLPKKLAAMLNEKLMSRWFNHANYGLEPKNRMKIPIVNDYLPSQILQGAIKVKPNIKEFTETSAIFEDGTVVDNLDAVIFATGYNMTFPFLNDFSLEMDESNAPLYKNVFPVQVEKPTIAFLGLIQPLGPIMPTVELQARWATRVFKGEAHLPPKRKMEKYIIRSMKTKSKWFGITKSLSLQTHYIDYVNELSVEIGNCPNLMYLFLTDPKLAWEVAFGPCTPFQHRLSGPGKWQGARKAILTQWERTLKPNRTRIVQKNQDAMQRLPYNLILILSAIIVVL

Genome annotation databases

Similar Proteins

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