A0A6I8PS11 · A0A6I8PS11_XENTR
- ProteinFlavin-containing monooxygenase
- Genefmo1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids527 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
Catalytic activity
- N,N-dimethylaniline + NADPH + O2 + H+ = N,N-dimethylaniline N-oxide + NADP+ + H2OThis reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | hypotaurine dehydrogenase activity | |
Molecular Function | N,N-dimethylaniline monooxygenase activity | |
Molecular Function | NADP binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFlavin-containing monooxygenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionA0A6I8PS11
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length527
- Mass (Da)59,738
- Last updated2021-06-02 v2
- ChecksumE88841623601C3CE