A0A6I8NLW2 · A0A6I8NLW2_ORNAN
- ProteinEctonucleoside triphosphate diphosphohydrolase 1
- GeneENTPD1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids516 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 2 H2O + ITP = 2 H+ + IMP + 2 phosphateThis reaction proceeds in the forward direction.
- 2 H2O + UTP = 2 H+ + 2 phosphate + UMPThis reaction proceeds in the forward direction.
- ADP + H2O = AMP + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + 2 H2O = AMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- ATP + H2O = ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- CDP + H2O = CMP + H+ + phosphateThis reaction proceeds in the forward direction.
- CTP + 2 H2O = CMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- CTP + H2O = CDP + H+ + phosphateThis reaction proceeds in the forward direction.
- GDP + H2O = GMP + H+ + phosphateThis reaction proceeds in the forward direction.
- GTP + 2 H2O = GMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- GTP + H2O = GDP + H+ + phosphateThis reaction proceeds in the forward direction.
- H2O + IDP = H+ + IMP + phosphateThis reaction proceeds in the forward direction.
- H2O + ITP = H+ + IDP + phosphateThis reaction proceeds in the forward direction.
- H2O + UDP = H+ + phosphate + UMPThis reaction proceeds in the forward direction.
- H2O + UTP = H+ + phosphate + UDPThis reaction proceeds in the forward direction.
- a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H+ + phosphateThis reaction proceeds in the forward direction.
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H+ + phosphateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | GDP phosphatase activity | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | UDP phosphatase activity | |
Biological Process | nucleoside diphosphate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEctonucleoside triphosphate diphosphohydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Monotremata > Ornithorhynchidae > Ornithorhynchus
Accessions
- Primary accessionA0A6I8NLW2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-42 | Helical | ||||
Sequence: NVLVILGFFFAIAIIALITVGV | ||||||
Transmembrane | 482-505 | Helical | ||||
Sequence: VYILLMVAFSLVLVAVFLMGWLIF |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Subunit
Homodimer; disulfide-linked.
Structure
Sequence
- Sequence statusComplete
- Length516
- Mass (Da)57,581
- Last updated2020-08-12 v1
- ChecksumCC2870A69693D276
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8PHS0 | A0A6I8PHS0_ORNAN | ENTPD1 | 511 | ||
A0A6I8P9P2 | A0A6I8P9P2_ORNAN | ENTPD1 | 464 |
Keywords
- Technical term