A0A6I8N415 · A0A6I8N415_ORNAN
- ProteinMitogen-activated protein kinase
- GeneMAPK3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids389 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by threonine and tyrosine phosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 82 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | early endosome | |
Cellular Component | focal adhesion | |
Cellular Component | Golgi apparatus | |
Cellular Component | late endosome | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | caveolin-mediated endocytosis | |
Biological Process | intracellular signal transduction | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of cytoskeleton organization | |
Biological Process | regulation of early endosome to late endosome transport | |
Biological Process | regulation of Golgi inheritance | |
Biological Process | regulation of stress-activated MAPK cascade |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Monotremata > Ornithorhynchidae > Ornithorhynchus
Accessions
- Primary accessionA0A6I8N415
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-45 | Disordered | |||
Domain | 52-340 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length389
- Mass (Da)43,445
- Last updated2020-08-12 v1
- ChecksumF2DBFC3DC4AB14D2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8NRF4 | A0A6I8NRF4_ORNAN | MAPK3 | 350 |
Keywords
- Technical term