A0A6I4NVR0 · A0A6I4NVR0_9FLAO
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids658 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = H2O + trans-urocanate
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Flavobacterium
Accessions
- Primary accessionA0A6I4NVR0
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 84-210 | Urocanase N-terminal | ||||
Sequence: MYARPIDEYPGKSVQAKAIMHMIQNNLDYAVAQHPHELITYGGNGAVFQNWAQYLLTMQYLSEMTDEQTLTMYSGHPMGLFPSHKEAPRVVVTNGMVIPNYSKPDDWEKMNALGVSQYGQMTAGSYM | ||||||
Domain | 213-427 | Urocanase Rossmann-like | ||||
Sequence: GPQGIVHGTTITVLNGFRKIKKNPEGNLFVTSGLGGMSGAQPKAGNIAGCITVCAEVNPKITKIRHEQGWINEIVTSTEELVERVNSAKANKEIVSIAYLGNVVDVWETFDKENIQIDLGSDQTSLHNPWAGGYYPVGISFEEANEMMANNPDLFKEKVQETLRRHAAAINKHTAKGTYFFDYGNAFLLEASRAGADVMAENNIDFKYPSYVQDI | ||||||
Domain | 433-636 | Urocanase C-terminal | ||||
Sequence: FDYGFGPFRWVCTSGKPEDLQKTDAIASQVLEEMAKTAPDEIQQQMQDNIKWIKGAQENKLVVGSQARILYADAEGRIKIAEAFNQAIAKGEIGTVVLGRDHHDVSGTDSPYRETSNIYDGSRFTADMAIQNVIGDSFRGATWVSIHNGGGVGWGEVINGGFGMVLDGSKEASKRLASMLFWDVNNGISRRSWARNEEAIFAIK |
Sequence similarities
Belongs to the urocanase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length658
- Mass (Da)73,445
- Last updated2020-08-12 v1
- Checksum8BA49E63927891C9