A0A6I4NJ30 · A0A6I4NJ30_9FLAO
- ProteinSuccinate--CoA ligase [ADP-forming] subunit alpha
- GenesucD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids290 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
- GTP + succinate + CoA = succinyl-CoA + GDP + phosphate
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-20 | CoA (UniProtKB | ChEBI) | |||
Binding site | 43 | CoA (UniProtKB | ChEBI) | |||
Binding site | 96-98 | CoA (UniProtKB | ChEBI) | |||
Binding site | 159 | substrate; ligand shared with subunit beta | |||
Active site | 248 | Tele-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | nucleotide binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit alpha
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Flavobacterium
Accessions
- Primary accessionA0A6I4NJ30
Proteomes
Interaction
Subunit
Heterotetramer of two alpha and two beta subunits.
Structure
Sequence
- Sequence statusComplete
- Length290
- Mass (Da)29,804
- Last updated2020-08-12 v1
- Checksum9F4CE2A9CF057410
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WSTB01000003 EMBL· GenBank· DDBJ | MWB93963.1 EMBL· GenBank· DDBJ | Genomic DNA |