A0A6I4NG00 · A0A6I4NG00_9FLAO

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59carbamoyl phosphate (UniProtKB | ChEBI)
Binding site60carbamoyl phosphate (UniProtKB | ChEBI)
Binding site87L-aspartate (UniProtKB | ChEBI)
Binding site109carbamoyl phosphate (UniProtKB | ChEBI)
Binding site137carbamoyl phosphate (UniProtKB | ChEBI)
Binding site140carbamoyl phosphate (UniProtKB | ChEBI)
Binding site170L-aspartate (UniProtKB | ChEBI)
Binding site224L-aspartate (UniProtKB | ChEBI)
Binding site265carbamoyl phosphate (UniProtKB | ChEBI)
Binding site266carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      GON26_02405

Organism names

Accessions

  • Primary accession
    A0A6I4NG00

Proteomes

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-150Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain157-302Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    34,168
  • Last updated
    2020-08-12 v1
  • Checksum
    5AE7880F3BA88CAF
MKELSVNHLLGIKYINENDINLIFETADHFKEVINRPIKKVPSLRDITIANIFFENSTRTKLSFELAQKRLSADVISFSAAQSSVKKGETLIDTVNNILSMKVDMVVMRHSNPGAAYFLSKNVKASIVNAGDGAHEHPTQALLDSYSIREKLGDVAGKKVVIVGDILHSRVALSNIYALQMQGAEVKVCGPKTLIPRYIESLGVTVEPNLRKALEWCDVANMLRVQNERMDVNFFPSTREYAQQYGVDKPLLDSLGKEIVIMHPGPINRGVEITSEVADSNHSVILNQVENGVAIRMAVIYLLASKIQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WSTB01000001
EMBL· GenBank· DDBJ
MWB93198.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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