A0A6I2FBM5 · A0A6I2FBM5_9MICO

Function

function

Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site246-248NAD+ (UniProtKB | ChEBI)
Binding site246-248NADP+ (UniProtKB | ChEBI)
Binding site296-298NAD+ (UniProtKB | ChEBI)
Binding site296-298NADP+ (UniProtKB | ChEBI)
Binding site298K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site300K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Active site303Thioimidate intermediate
Binding site303K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGMP reductase activity
Molecular FunctionIMP dehydrogenase activity
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate reductase
      (GMPR
      )

Gene names

    • Name
      guaB1
    • ORF names
      GE115_18040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CFH 90414
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Agromyces

Accessions

  • Primary accession
    A0A6I2FBM5

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-473IMP dehydrogenase/GMP reductase

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    50,247
  • Last updated
    2020-08-12 v1
  • Checksum
    A47AF2A4D63C72EF
MEFYRTTPTHDLTYSDVFLVPSRSGVTSRLDVSLDSGDGSGATVPIVSANMNSVTGPTLAASLARRGGIGVLPQDLHLQDLAEAIRSVKEQSPVFDTPVVFAPDATAADALEVLPPAVGHGIVLQDERGGFAGCIAAERLASALPDARLGDLVHAGLASLDAEDVDTPRRAFDLMVEAGLEFAPVLRHGEVVGTLSRRSALRGTIYRPNVDADGRLRVAAALGINGDVVAKARALADAGVDLFVIDTAHGHQEGMLRAIRAVRDLDLGLPIAAGNVVTAAAVADLVDAGADILKVGVGPGAMCTTRMMTAVGRPQFSAVLETAEAARELGAHVWADGGVRYPRDVALALAAGASAVMIGSWFAGTIEAPGRLRRDASGRLFKESWGMASTKAVRERFDRLSPYELARRELFAEGISSSSIYLDPMRPSVEDLLDMITSGVRSSATYAGARTLAEFRERALVGIQSAAGYEEGKALPVSW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WJIF01000017
EMBL· GenBank· DDBJ
MRG61761.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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