A0A6I2FBM5 · A0A6I2FBM5_9MICO
- ProteinGMP reductase
- GeneguaB1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids479 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.
Catalytic activity
- IMP + NH4+ + NADP+ = GMP + NADPH + 2 H+
Cofactor
Pathway
Purine metabolism; IMP biosynthesis via salvage pathway.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 246-248 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 246-248 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 296-298 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 296-298 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 298 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 300 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Active site | 303 | Thioimidate intermediate | |||
Binding site | 303 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | GMP reductase activity | |
Molecular Function | IMP dehydrogenase activity | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGMP reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Agromyces
Accessions
- Primary accessionA0A6I2FBM5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length479
- Mass (Da)50,247
- Last updated2020-08-12 v1
- ChecksumA47AF2A4D63C72EF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WJIF01000017 EMBL· GenBank· DDBJ | MRG61761.1 EMBL· GenBank· DDBJ | Genomic DNA |