A0A6I2FA96 · A0A6I2FA96_9MICO
- ProteinPhospho-N-acetylmuramoyl-pentapeptide-transferase
- GenemraY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids365 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Catalytic activity
- UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
Cofactor
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 185 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 267 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phospho-N-acetylmuramoyl-pentapeptide-transferase activity | |
Molecular Function | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospho-N-acetylmuramoyl-pentapeptide-transferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Agromyces
Accessions
- Primary accessionA0A6I2FA96
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 51-72 | Helical | |||
Transmembrane | 79-97 | Helical | |||
Transmembrane | 117-134 | Helical | |||
Transmembrane | 155-180 | Helical | |||
Transmembrane | 192-211 | Helical | |||
Transmembrane | 237-256 | Helical | |||
Transmembrane | 290-311 | Helical | |||
Transmembrane | 339-360 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the glycosyltransferase 4 family. MraY subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)39,338
- Last updated2020-08-12 v1
- Checksum89EB310538836BD1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WJIF01000014 EMBL· GenBank· DDBJ | MRG61519.1 EMBL· GenBank· DDBJ | Genomic DNA |