A0A6I1EGL4 · A0A6I1EGL4_9BURK

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site98-100substrate
Binding site135-138substrate; in site B
Binding site145-147substrate
Binding site193substrate
Active site194Proton donor/acceptor
Active site324
Binding site325substrate
Binding site330-332substrate
Site337Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      GBM95_10670

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ASD393
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sutterellaceae > Sutterella

Accessions

  • Primary accession
    A0A6I1EGL4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-348Fumarate lyase N-terminal
Domain414-467Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    51,962
  • Last updated
    2020-08-12 v1
  • Checksum
    ACB3BC14574C55C9
MDQFRIEKDSMGEVKVPNEKYWGAQTERSFENFKIGIEKMPVEIVRAFALLKGACALANQEFGKLDDKRAAAIEQACDEAFEGKLDGNFPLAVWQTGSGTQSNMNMNEVFANRAIEILGGNFRDKSSLSKDQLVHPNDHVNMSQSSNDTFPSALSIMSVVETTNYLLPRLEGLEKALYAKAEEFKDLIKSGRTHLQDATPLTLGQEFSGYASMLTHSREAILAALEPCRELAIGGTAVGTGINSPEGFGVKVAEILTKKTGIKFKDAPNKFHALTSHDAVCLLQGALAGLAADLMKIANDIRWLASGPRCGLGEINIPANEPGSSIMPGKVNPTQCEAVTMVAVQVMGNATCINFAASQGNFELNVFKPVIAYNLIQSIKNLADVMKSFEIHCVTGITANKERLHDLMERSLMLVTALSPLVGYMNAAKIAHYAHVNNKSLKEAALELNLCTAEQFDQYVDPTKMIHPNPVKKCCCK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WEHX01000115
EMBL· GenBank· DDBJ
KAB7653914.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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