A0A6I1BWD5 · A0A6I1BWD5_BIFLN

  • Protein
    Hydroxyethylthiazole kinase
  • Gene
    thiM
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site70substrate
Binding site145ATP (UniProtKB | ChEBI)
Binding site217ATP (UniProtKB | ChEBI)
Binding site244substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionhydroxyethylthiazole kinase activity
Molecular Functionmagnesium ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxyethylthiazole kinase
  • EC number
  • Alternative names
    • 4-methyl-5-beta-hydroxyethylthiazole kinase
      (TH kinase
      ; Thz kinase
      )

Gene names

    • Name
      thiM
    • ORF names
      GBJ98_07515
      , GBK06_08110

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BIOML-A283
    • BIOML-A284
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium

Accessions

  • Primary accession
    A0A6I1BWD5

Proteomes

Family & Domains

Sequence similarities

Belongs to the Thz kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    32,425
  • Last updated
    2020-08-12 v1
  • Checksum
    C09933EE7CB092BF
MSNSASSFTGVSSGCTAGTPVPADSPIRDNIADAVRRVRETTPLAQSFTNFVTINLVANAQLAAGGTAAMSFLPDDVIETAKIAGANYINVGTLLPFYKDALPEIAQRLNYLDKPWVLDPVAAGIGRTRTAILQAFKAAPPTMIRANASEVIALANMWGLNTETVGDASEHRPAGVESVDDVESATGAAVALAQYLTEQHAKHSSHDASTRCAVAVSGIADLVTDGETVYRLPGGSAMMTKITGAGCSLGGVAATYLAVSDPLTAALSASLLYNRAGEVADTTSHGPGSFQVAFLDALWNVTAEQVAESEILVQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WDZO01000016
EMBL· GenBank· DDBJ
KAB6912384.1
EMBL· GenBank· DDBJ
Genomic DNA
WDZP01000017
EMBL· GenBank· DDBJ
KAB6917607.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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