A0A6H5HLJ3 · A0A6H5HLJ3_9HEMI
- Protein15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids795 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Catalytic activity
- (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H+This reaction proceeds in the forward direction.
- 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H+This reaction proceeds in the forward direction.
- 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H+ = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+This reaction proceeds in the forward direction.
- prostaglandin A1 + NAD+ = 15-oxo-prostaglandin A1 + NADH + H+This reaction proceeds in the forward direction.
- prostaglandin E1 + NAD+ = 15-oxoprostaglandin E1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D1 + NAD+ = 17-oxoresolvin D1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D1 + NAD+ = 8-oxoresolvin D1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D2 + NAD+ = 16-oxoresolvin D2 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D2 + NAD+ = 7-oxoresolvin D2 + NADH + H+This reaction proceeds in the forward direction.
- resolvin E1 + NAD+ = 18-oxo-resolvin E1 + NADH + H+This reaction proceeds in the forward direction.
- lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Miridae > Dicyphina > Nesidiocoris
Accessions
- Primary accessionA0A6H5HLJ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MPAKPDPKLQPKPAGSKTPPTANAD | ||||||
Region | 717-741 | Disordered | ||||
Sequence: VSKDERKSGQTACKTTGSSGVRPVR |
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length795
- Mass (Da)87,034
- Last updated2020-08-12 v1
- Checksum729C97AAC38478FF
Keywords
- Technical term