A0A6H0CGV1 · A0A6H0CGV1_9ACTN

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

151250100150200250300350400450500
TypeIDPosition(s)Description
Binding site208ATP (UniProtKB | ChEBI)
Active site210N6-AMP-lysine intermediate
Binding site215ATP (UniProtKB | ChEBI)
Binding site230ATP (UniProtKB | ChEBI)
Binding site259ATP (UniProtKB | ChEBI)
Binding site299ATP (UniProtKB | ChEBI)
Binding site374ATP (UniProtKB | ChEBI)
Binding site380ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular Functionmetal ion binding
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable DNA ligase
  • EC number
  • Alternative names
    • Polydeoxyribonucleotide synthase [ATP]

Gene names

    • Name
      lig
    • ORF names
      HB370_07340

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 40868
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A6H0CGV1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain287-414ATP-dependent DNA ligase family profile

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    55,078
  • Last updated
    2020-08-12 v1
  • Checksum
    24A24E31E0C64E3D
MLLTRLAEVSREVAATAARSRKTALLAELFREAEPADVPIVIPYLAGRLPQGRLGVGWKVLGRPVPPAAEPTLTVREVDARLAELGKVAGPGAQAERSRVVGELMGAATEAEQRFLLGLLTGEVRQGALDAVAVEGLARATQADPADVRRAVMLAGSLQTVAEALLGEGPAALERFRLTVGRPVLPMLAHSASSVAEAVRKLGACAVEEKLDGIRVQVHRDGERVRIHTRTLDDITGRLPEVTAAALALPCEGFILDGEVISFDAAGRPRSFQETAGRVGSRSDVARAAEEVPVSPVFFDALAVDGRDLLDLPFAERHAELARLVPEPMRVRRTLVSGPGDLAEAERFLADTLARGHEGVVVKALDAPYSAGRRGASWLKVKPVHTLDLVVLAAEWGHGRRTGRLSNLHLGARTEDGGFAMLGKTFKGMTDAMLAWQTERLRELAVEDDGRVVRVRPELVVEIAYDGLQRSTRYPAGVTLRFARVLRYREDKRPEEADTVQALLAAHPEAGT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP050504
EMBL· GenBank· DDBJ
QIS69825.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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