A0A6H0CGV1 · A0A6H0CGV1_9ACTN
- ProteinProbable DNA ligase
- Genelig
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids512 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Catalytic activity
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 208 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 210 | N6-AMP-lysine intermediate | ||||
Sequence: K | ||||||
Binding site | 215 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 230 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 259 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 299 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 374 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 380 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA ligase (ATP) activity | |
Molecular Function | metal ion binding | |
Biological Process | cell division | |
Biological Process | DNA biosynthetic process | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable DNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A6H0CGV1
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 287-414 | ATP-dependent DNA ligase family profile | ||||
Sequence: RAAEEVPVSPVFFDALAVDGRDLLDLPFAERHAELARLVPEPMRVRRTLVSGPGDLAEAERFLADTLARGHEGVVVKALDAPYSAGRRGASWLKVKPVHTLDLVVLAAEWGHGRRTGRLSNLHLGART |
Sequence similarities
Belongs to the ATP-dependent DNA ligase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length512
- Mass (Da)55,078
- Last updated2020-08-12 v1
- Checksum24A24E31E0C64E3D
Keywords
- Technical term