A0A6G9W282 · A0A6G9W282_TARGR
- ProteinSodium channel protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1972 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Caudata > Salamandroidea > Salamandridae > Pleurodelinae > Taricha
Accessions
- Primary accessionA0A6G9W282
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 128-151 | Helical | ||||
Sequence: ILIHSVFSMIIMCTILTNCVFMTF | ||||||
Transmembrane | 254-274 | Helical | ||||
Sequence: VMILTVFCLSVFALIGLQLFM | ||||||
Transmembrane | 387-414 | Helical | ||||
Sequence: YMIFFVLVIFVGSFYLVNLILAVVAMAY | ||||||
Transmembrane | 739-764 | Helical | ||||
Sequence: VNLFVMDPFVDLAITICIVLNTLFMA | ||||||
Transmembrane | 776-795 | Helical | ||||
Sequence: GVLSVGNLVFTGIFTAEMFL | ||||||
Transmembrane | 857-885 | Helical | ||||
Sequence: LIKIIGNSVGALGNLTLVLAIIVFIFAVV | ||||||
Transmembrane | 944-970 | Helical | ||||
Sequence: AMCLCVFMMVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1191-1209 | Helical | ||||
Sequence: WFETFIIFMILLSSGALAF | ||||||
Transmembrane | 1230-1249 | Helical | ||||
Sequence: VFTYIFILEMLLKWLAYGFV | ||||||
Transmembrane | 1261-1284 | Helical | ||||
Sequence: FLIVAVSIVSLVANALGFSELGAI | ||||||
Transmembrane | 1305-1333 | Helical | ||||
Sequence: MRVVVNALVGAIPSIMNVLLVCLIFWLIF | ||||||
Transmembrane | 1433-1456 | Helical | ||||
Sequence: YMYFVIFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1515-1533 | Helical | ||||
Sequence: AFDIFIMILICLNMVTMMV | ||||||
Transmembrane | 1545-1563 | Helical | ||||
Sequence: VLYQINLVFIVFFTTECVL | ||||||
Transmembrane | 1575-1595 | Helical | ||||
Sequence: IGWNIFDFVVVILSIVGMFLA | ||||||
Transmembrane | 1632-1660 | Helical | ||||
Sequence: LLFALMMSLPALFNIGLLLFLVMFIFSIF | ||||||
Transmembrane | 1735-1758 | Helical | ||||
Sequence: IFFFVSYLIISFLIVVNMYIAIIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-57 | Basic and acidic residues | ||||
Sequence: KRIAEEKAKKPPKPDTXHRDDDDENKPKPSS | ||||||
Region | 27-65 | Disordered | ||||
Sequence: KRIAEEKAKKPPKPDTXHRDDDDENKPKPSSDLEAGKNV | ||||||
Domain | 131-420 | Ion transport | ||||
Sequence: HSVFSMIIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLVKIISRGFCIDGFTFLRDPWNWLDFSVISMAYXTEFVDLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVIWPVNFNESYFGNGSRGFDWDEYIHNTTNFYYLHGALDPLLCGNSSDAGQCPEGYKCMKAGINPNYGYTSFDSFGWAFLALFRLMTQDAXENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYDEQNQA | ||||||
Coiled coil | 411-452 | |||||
Sequence: AMAYDEQNQATLEEAEKKEAEFKAMLEQLKKQQEEAQAAVAT | ||||||
Region | 481-526 | Disordered | ||||
Sequence: SSKSAKERRNRRKKKKQKELSEGEEKGDNEKAVKSESDDGMKRRGF | ||||||
Compositional bias | 497-526 | Basic and acidic residues | ||||
Sequence: QKELSEGEEKGDNEKAVKSESDDGMKRRGF | ||||||
Domain | 542-693 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: SLLSIPGSPYLSRQNSKSSVFSFKGRFREPASENEFADDEHSTVEESEGRRDSLFVPFRSNERRNSYSGYSQGSRSSRIFPNLRRNMKRNSTVDCNGVVSLIGGPGANMPGGRLLPEPSTEVDVKKTNSRSLRVSMDQLNASFGRKDRANSA | ||||||
Domain | 746-976 | Ion transport | ||||
Sequence: PFVDLAITICIVLNTLFMAMEHYPMTEQFEGVLSVGNLVFTGIFTAEMFLKLVAMDPYYYFQEGWNIFDGFIVSLSLMELGLQDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKINSECVLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLCVFMMVMVIGNLVVLNLFLALLLSSFSAD | ||||||
Domain | 984-1184 | Sodium ion transport-associated | ||||
Sequence: DGEMNNLQISVIRIKKGVAWLKNKVREFIQTYFKRRDADEVKPLDELYEKKINCIANHTRADINRDMDYQKNGNGTTSGIGSSMEKYIIEGDHMSFIHNPNLTVRVPIAMGESDFENLNTEEFSSESDAEGKDKTDDTSSSEGSTIDIKPEAEEKPVDQPEEYLDPDACFTEGCVARFKVCQVSVDDGFGKQWWTLRKTCF | ||||||
Region | 1100-1147 | Disordered | ||||
Sequence: NLNTEEFSSESDAEGKDKTDDTSSSEGSTIDIKPEAEEKPVDQPEEYL | ||||||
Compositional bias | 1108-1123 | Basic and acidic residues | ||||
Sequence: SESDAEGKDKTDDTSS | ||||||
Compositional bias | 1130-1145 | Basic and acidic residues | ||||
Sequence: DIKPEAEEKPVDQPEE | ||||||
Domain | 1189-1465 | Ion transport | ||||
Sequence: HNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTMLEYLDKVFTYIFILEMLLKWLAYGFVKFFTNAWCWLDFLIVAVSIVSLVANALGFSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCYNETAEARFEVEEIENETECMRLIETNPVEIRWKNVKINFDNVGAGYLALLQIATFKGWMDIMYAAVDSRKVHQQPQYEDNIYMYMYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1514-1768 | Ion transport | ||||
Sequence: QAFDIFIMILICLNMVTMMVETDDQSPYMENVLYQINLVFIVFFTTECVLKLFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYAKKEGGIDDMFNFETFGNSMICLFQVTTSAGWDGLLLPILNRPPDCDPKTENPGSPASGNCGNPSVGIFFFVSYLIISFLIVVNMYIAIILENFGVATEES | ||||||
Region | 1913-1972 | Disordered | ||||
Sequence: ASTKLENGGTNPDKKEGTPSTASLPSYDSVTKPEKEKQERIEDGRRDRVKKLKDVRESKC | ||||||
Compositional bias | 1916-1940 | Polar residues | ||||
Sequence: KLENGGTNPDKKEGTPSTASLPSYD | ||||||
Compositional bias | 1942-1972 | Basic and acidic residues | ||||
Sequence: VTKPEKEKQERIEDGRRDRVKKLKDVRESKC |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,972
- Mass (Da)224,685
- Last updated2020-08-12 v1
- ChecksumDF6A0B7B0D2B9210
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-57 | Basic and acidic residues | ||||
Sequence: KRIAEEKAKKPPKPDTXHRDDDDENKPKPSS | ||||||
Compositional bias | 497-526 | Basic and acidic residues | ||||
Sequence: QKELSEGEEKGDNEKAVKSESDDGMKRRGF | ||||||
Compositional bias | 1108-1123 | Basic and acidic residues | ||||
Sequence: SESDAEGKDKTDDTSS | ||||||
Compositional bias | 1130-1145 | Basic and acidic residues | ||||
Sequence: DIKPEAEEKPVDQPEE | ||||||
Compositional bias | 1916-1940 | Polar residues | ||||
Sequence: KLENGGTNPDKKEGTPSTASLPSYD | ||||||
Compositional bias | 1942-1972 | Basic and acidic residues | ||||
Sequence: VTKPEKEKQERIEDGRRDRVKKLKDVRESKC |