A0A6G9IL12 · A0A6G9IL12_HUMAN

  • Protein
    ATP synthase subunit a
  • Gene
    ATP6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentproton-transporting ATP synthase complex, coupling factor F(o)
Molecular Functionproton transmembrane transporter activity
Biological Processproton motive force-driven ATP synthesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP synthase subunit a

Gene names

    • Name
      ATP6

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A6G9IL12

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-31Helical
Transmembrane67-86Helical
Transmembrane98-117Helical
Transmembrane137-158Helical
Transmembrane164-184Helical
Transmembrane191-222Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Sequence similarities

Belongs to the ATPase A chain family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    24,757
  • Last updated
    2020-08-12 v1
  • Checksum
    2240BEF4C9E5E216
MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFITTTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVGLYLHDNT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN398783
EMBL· GenBank· DDBJ
QIQ24731.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849494
EMBL· GenBank· DDBJ
QKT21961.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849501
EMBL· GenBank· DDBJ
QKT22052.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849502
EMBL· GenBank· DDBJ
QKT22065.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849508
EMBL· GenBank· DDBJ
QKT22143.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849627
EMBL· GenBank· DDBJ
QKT23690.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849637
EMBL· GenBank· DDBJ
QKT23820.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849641
EMBL· GenBank· DDBJ
QKT23872.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849644
EMBL· GenBank· DDBJ
QKT23911.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849646
EMBL· GenBank· DDBJ
QKT23937.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849649
EMBL· GenBank· DDBJ
QKT23976.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849650
EMBL· GenBank· DDBJ
QKT23989.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849651
EMBL· GenBank· DDBJ
QKT24002.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849655
EMBL· GenBank· DDBJ
QKT24054.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849662
EMBL· GenBank· DDBJ
QKT24145.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849664
EMBL· GenBank· DDBJ
QKT24171.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849666
EMBL· GenBank· DDBJ
QKT24197.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849668
EMBL· GenBank· DDBJ
QKT24223.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849674
EMBL· GenBank· DDBJ
QKT24301.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849843
EMBL· GenBank· DDBJ
QKT26498.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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