A0A6G6WEH5 · A0A6G6WEH5_9ACTN

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site163(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site167-169(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site274Plays an important role in substrate specificity
Binding site289(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      G5V58_13010

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R-3366
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Nocardioidaceae > Nocardioides

Accessions

  • Primary accession
    A0A6G6WEH5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue275N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-122Serine hydroxymethyltransferase-like
Domain156-428Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    51,472
  • Last updated
    2020-08-12 v1
  • Checksum
    992E6B686076FEBB
MADVDALISSAYQQILEVIGSVEPRIADATRQELVDQRASLKLIASENYASPAVLLTMGTWFSDKYAEGTVGHRFYAGCQNVDTVESLAAEHARELFGAPYAYAQPHSGIDANLVAFWSILAHRVEGPWLEKAGAKNVNDLTDEDWETLRHELGNQRLLGMSLDAGGHLTHGFRPNISGKMFHQQQYGTDPATGLLDYDQVAAKAREFKPLILVAGYSAYPRRVDFAKMREIADEVGATLMVDMAHFAGLVAGKVFTGDEDPVPHAHVVTTTTHKSLRGPRGGLVLAQEEFASSVDRGCPMVLGGPLSHMMAAKAVALAEARQDSFRTYAQNIANNAQSLAEGFLKRGATLVTGGTDNHLVLLDVSSFGLTGRQAESALLDAGVVTNRNSVPADPNGAWYTSGIRLGTPALTTRGFGHDEFDTVAQLIVQVLQNTQPGTTKDGAASKASYVLADGVADKVKDASSELLDKHPLYPGLTLD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP049257
EMBL· GenBank· DDBJ
QIG43557.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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