A0A6G6W824 · A0A6G6W824_9ACTN

  • Protein
    Malate synthase G
  • Gene
    glcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site119acetyl-CoA (UniProtKB | ChEBI)
Binding site126-127acetyl-CoA (UniProtKB | ChEBI)
Binding site269acetyl-CoA (UniProtKB | ChEBI)
Binding site306acetyl-CoA (UniProtKB | ChEBI)
Active site332Proton acceptor
Binding site332glyoxylate (UniProtKB | ChEBI)
Binding site423Mg2+ (UniProtKB | ChEBI)
Binding site423glyoxylate (UniProtKB | ChEBI)
Binding site448-451glyoxylate (UniProtKB | ChEBI)
Binding site451Mg2+ (UniProtKB | ChEBI)
Binding site532acetyl-CoA (UniProtKB | ChEBI)
Active site623Proton donor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmagnesium ion binding
Molecular Functionmalate synthase activity
Biological Processglyoxylate catabolic process
Biological Processglyoxylate cycle
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malate synthase G
  • EC number

Gene names

    • Name
      glcB
    • ORF names
      G5V58_00060

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R-3366
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Nocardioidaceae > Nocardioides

Accessions

  • Primary accession
    A0A6G6W824

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue609Cysteine sulfenic acid (-SOH)

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-78Malate synthase N-terminal
Domain161-228Malate synthase G alpha-beta insertion
Domain329-570Malate synthase TIM barrel
Domain585-664Malate synthase C-terminal

Sequence similarities

Belongs to the malate synthase family. GlcB subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    713
  • Mass (Da)
    77,403
  • Last updated
    2020-08-12 v1
  • Checksum
    0A918FE297C0A202
MSTERITVGGLEVAPELHAFVRDEALPDSGLDEAAFWSGFEALVAEFAPRNRELLARRDELQTALDEWHTAHPGPVTDQDSYVSLLRELGYLVEEPEDFEITTEGVDDAVALQAGPQLVVPVLNARFAANAANARWGSLYDALYGTDAIDEADGKEKGSSYNATRGAEVIRRARAFLDEHFALAEGSHADVTGYAVEDGALAPALADPAQLVGWRGDPDAPEGVLLVHHGLHVEIQVDREDRIGRDDPAGVKDLLLESAVSTIMDLEDSIATVDAEDKVAAYRNWLRLNQGTLTADVSKGGETFTRHLEEDRLYDGPRGQVVLPGRSLLFVRQVGHLMTTDAVLHEGQEIPEGVLDAVVTALCALVDIQGRSELANSRTGSMYAVKPKMHGPDEVRFTDDLFAAVEDLLGLGRGAIKLGIMDEERRTSANLKACIHAARGRVAFINTGFLDRTGDELHTSMLGGAMIRKGDMKSTAWIQAYEDQNVDIGLACGFRGKAQIGKGMWAMPDEMAAMLEQKVGHPQAGASCAWVPSPTAATLHALHYHQVDVAARQQELAAGGRRTTLEQLLTVPIADAPDWSNEDRTAEIENNLQGILGYVKRWVDDGVGCSKVPDIHGTALMEDRATCRISSQHVANWLRHGVVSAEEVEAAFRRMADVVDEQQGGDGYVPMAPAYDGQAFGAAHDLVFEGLAQPSGYTEPILHRRRRARKAEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP049257
EMBL· GenBank· DDBJ
QIG41374.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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