A0A6G6J4K4 · A0A6G6J4K4_PSENT

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site26substrate
Site26Important for catalytic activity
Binding site260substrate
Site260Important for catalytic activity
Binding site357substrate
Binding site384substrate
Binding site461substrate
Binding site469substrate
Binding site473substrate
Binding site520substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • Name
      tkt
    • ORF names
      G5B91_29965

Organism names

  • Taxonomic identifier
  • Strain
    • HBP1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A6G6J4K4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain354-525Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    665
  • Mass (Da)
    71,970
  • Last updated
    2020-08-12 v1
  • Checksum
    47B7349241D8B491
MPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLKHNPSNPQWADRDRFVLSNGHGSMLIYSLLHLTGYDVTVDDLKNFRQMHSRTPGHPEYGYTAGVETTTGPLGQGIANAVGMALAEKVLAAQFNRDGHSIVDHYTYAFLGDGCMMEGISHEVASLAGTLRLNKLIAFYDDNGISIDGEVHGWFTDDTPKRFEAYGWQVIRNVDGHDADEIKTAIDTARKSDAPTLICCKTIIGFGSPNKQGKEESHGAALGVDEVAATRAALGWNHAPFEVPADIYAEWSAKDSGATREAEWNKRFAAYQAAHPELAAEFERRVAGELPADFAEKAAAYVADVALKGETIASRKASQNALNAFGPLLPELLGGSADLAGSNLTLWKGCKGVSADDANGNYLFYGVREFGMSAIMNGVALHGGFIPYGATFLIFMEYARNAVRMSALMKQRVLYVFTHDSIGLGEDGPTHQPIEQLASLRLTPNLDTWRPADAVESAVAWKYAIERADGPSALIFSRQNLPHQPRDAAQLADVARGAYVLKDCDGEPELILIATGSEVGLAVQAFDKLSAEGRKVRVVSMPSTSVFDQQDAGYKQAVLPVQVGARIAIEAAHADYWYKYVGLEGRVIGMTTFGESAPAPALFEHFGFTVENVLEVAAELLEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP049140
EMBL· GenBank· DDBJ
QIE90249.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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