A0A6G5Q8V7 · A0A6G5Q8V7_MIRFO

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • MF1
    • MF10
    • MF11
    • MF2
    • MF4
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Bresilioidea > Alvinocarididae > Mirocaris

Accessions

  • Primary accession
    A0A6G5Q8V7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane17-40Helical
Transmembrane52-79Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-104Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    104
  • Mass (Da)
    11,060
  • Last updated
    2020-08-12 v1
  • Checksum
    A660E837EA2C9532
LAAGIAHAGASVDMAIFSLHLAGVSSILGAVNFMTTCINMRMSGMTMDRMPLFVWSIFLTAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue104

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK591346
EMBL· GenBank· DDBJ
QBX58008.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591347
EMBL· GenBank· DDBJ
QBX58009.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591348
EMBL· GenBank· DDBJ
QBX58010.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591349
EMBL· GenBank· DDBJ
QBX58011.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591350
EMBL· GenBank· DDBJ
QBX58012.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591351
EMBL· GenBank· DDBJ
QBX58013.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591352
EMBL· GenBank· DDBJ
QBX58014.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591353
EMBL· GenBank· DDBJ
QBX58015.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591354
EMBL· GenBank· DDBJ
QBX58016.1
EMBL· GenBank· DDBJ
Genomic DNA
MK591355
EMBL· GenBank· DDBJ
QBX58017.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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