A0A6G4UK62 · A0A6G4UK62_KLEPN

  • Protein
    Lipid A 1-diphosphate synthase
  • Gene
    lpxT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionphosphotransferase activity, phosphate group as acceptor
Molecular Functionundecaprenyl-diphosphatase activity
Biological ProcessGram-negative-bacterium-type cell outer membrane assembly
Biological Processlipid A biosynthetic process
Biological Processlipopolysaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid A 1-diphosphate synthase
  • EC number
  • Alternative names
    • Kdo(2)-lipid A phosphotransferase
    • Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase

Gene names

    • Name
      lpxT
    • ORF names
      G4V33_25710

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 2069
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A6G4UK62

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Note: Transferase activity takes place on the periplamic side of the inner membrane.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane94-112Helical
Transmembrane172-192Helical
Transmembrane198-218Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-213Phosphatidic acid phosphatase type 2/haloperoxidase

Sequence similarities

Belongs to the LpxT phosphotransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    26,304
  • Last updated
    2020-08-12 v1
  • Checksum
    BF981BB2207DBBF6
MAMMKNRIPLILLLNIAGVALFCSWYLPANHGAWLPVDSAIFHFFNHGVSVSHAYAWLLAIINNRAFDACSLLAMGCLMLSYWLKAPTAGRRQIAIMGLVMLLAAVIINQLAQHLMPVQRASPSLFFSDITRVSDVVNFPTKDASKDSFPGDHGMMLLIFASFMWRYFGRHALGVALIIFVVFAFPRVMIGAHWFSDIAVGSLTAVLIGAPWVLMTPLSDKLIAFFDRYLPSRISAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAKYB010000031
EMBL· GenBank· DDBJ
NGN50343.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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