A0A6G1QCR0 · A0A6G1QCR0_9TELE

Function

function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functiongrowth factor activity
Molecular Functionplatelet-derived growth factor receptor binding
Biological Processplatelet-derived growth factor receptor signaling pathway
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of MAP kinase activity
Biological Processpositive regulation of protein autophosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-derived growth factor subunit B
  • Alternative names
    • PDGF-2
    • Platelet-derived growth factor B chain
    • Platelet-derived growth factor beta polypeptide

Gene names

    • ORF names
      EXN66_Car016128

Organism names

  • Taxonomic identifier
  • Strain
    • OARG1902GOOAL
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Anabantaria > Anabantiformes > Channoidei > Channidae > Channa

Accessions

  • Primary accession
    A0A6G1QCR0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_502622822522-521Platelet-derived growth factor subunit B

Interaction

Subunit

Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1. Interacts with LRP1. Interacts with SORL1 (via the N-terminal ectodomain). Interacts with CD82; this interaction inhibits PDGFB-mediated signaling pathway.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain68-167Platelet-derived growth factor (PDGF) family profile
Region173-202Disordered
Compositional bias269-302Basic and acidic residues
Region269-412Disordered
Compositional bias316-372Polar residues
Compositional bias373-412Basic and acidic residues
Compositional bias434-460Basic and acidic residues
Region434-521Disordered
Compositional bias473-487Polar residues
Compositional bias498-513Basic residues

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    521
  • Mass (Da)
    58,961
  • Last updated
    2020-08-12 v1
  • Checksum
    ACDC968BD6A46A7D
MSSWVQLLLVVLAACLRFGAAEEDPLPAALVELVRNSPISSIEDLQLLLLTDSVDEQEETSAANGGHRLPRSLNAQPAQQALCKVRTEVVEVTRAMLDRSNANFLLWPPCVEVQRCSGCCNTKSLQCVPVVTHTRYLQVMKIEYINKRVTYAKAVVSVVDHVECRCQLAPIPKKKSSRRQHSHQHRNQTLSQGHGQGQVKVHSKDELHQWDELKHNQRTQLEDLLDQHWNPRGDTFTDGGEGYSLPKEDPSLPGEAVLFAPHWAHNSTKLHGTEQRIELPENVERHDGRISEGNKTVFSEDKLVEGGDGLPLNSTEEKLNAGSRGSDEGTQTHSPSGLEDKSKSSISHTSGSSQGVTQNPQDKFSPAEETINESTRSRVRPTKEPNPEPRQLARQRNNETPEEKSTLEIEEAKLEEERKELLLIHKMLDQEKELVRQQQMKREEEERKKERDEDGQRHLHGTHHHHQHTTTHKPETTPTTTTRKPSAPTGPKLPARPNPTKRRTRKYRKRISKAAMRAMLM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias269-302Basic and acidic residues
Compositional bias316-372Polar residues
Compositional bias373-412Basic and acidic residues
Compositional bias434-460Basic and acidic residues
Compositional bias473-487Polar residues
Compositional bias498-513Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM015726
EMBL· GenBank· DDBJ
KAF3700441.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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