A0A6G0V722 · A0A6G0V722_9BILA

  • Protein
    Translation factor GUF1 homolog, mitochondrial
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Metalloprotease.
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site49-56GTP (UniProtKB | ChEBI)
Binding site109-113GTP (UniProtKB | ChEBI)
Binding site163-166GTP (UniProtKB | ChEBI)
Binding site1318Zn2+ (UniProtKB | ChEBI); catalytic
Active site1319
Binding site1322Zn2+ (UniProtKB | ChEBI); catalytic
Binding site1328Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionmitochondrial ribosome binding
Molecular Functionzinc ion binding
Biological Processpositive regulation of translation
Biological Processproteolysis
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Translation factor GUF1 homolog, mitochondrial
  • EC number
  • Alternative names
    • Elongation factor 4 homolog
      (EF-4
      )
    • GTPase GUF1 homolog
    • Ribosomal back-translocase

Gene names

    • ORF names
      FO519_000555

Organism names

  • Taxonomic identifier
  • Strain
    • NKZ332
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Panagrolaimomorpha > Panagrolaimoidea > Panagrolaimidae > Halicephalobus

Accessions

  • Primary accession
    A0A6G0V722

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain40-216Tr-type G
Domain663-801ENTH
Compositional bias767-802Basic and acidic residues
Region767-884Disordered
Compositional bias820-884Basic and acidic residues
Region911-930Disordered
Region957-1003Disordered
Compositional bias961-976Polar residues
Region1029-1082Disordered
Domain1227-1420Peptidase M12A
Compositional bias1433-1450Polar residues
Region1433-1479Disordered
Domain1479-1515ShKT
Domain1519-1555ShKT

Sequence similarities

Belongs to the GTP-binding elongation factor family. LepA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,555
  • Mass (Da)
    173,697
  • Last updated
    2020-08-12 v1
  • Checksum
    2B406935A86053EB
MLEKWYFSCRYGFRFYCTNLKISRVNAGERLSSIESFTPDRIRNFGIVAHVDHGKSSLADKLLQMTGVITDQEQDQFLDKLQVERDRGITVKAQTCSMVYKSHLLNLIDTPGHADFSFEVSRSLAVCDGVVFLVAANQGVQAQTLANFWLAFNNDLKMIPVINKIDIREANVEAVQNQLNTLFDFQPEEVLRISAKNGVNIDTVLDTLITRCPPPTVSPNDPFKALIFDSWYDQYRGAIAMISVKAGSIKKGQKISSFNEKKTYEVLEVLSAGQIGYIICNMKTVREAAVGETLFDPVEQDKVVPFPGFSAIQPTVYSGLFPVNSAQYEDLRMAVERLCLNDPSVVITPDSSSALGLGWRVGFLGVLHMEVFSQRLEQEYDADVILTSPSVEYRAIIKDNDTIRKKRYAGKGEIVFSDPSNFPELTDVEKFLEPVVQLTVIVPLEYLNTVNSLCSECRGERGDVSFIDNDRVIVKSKIPLAEVVVDFFERLKKLTSGYASFDYEPTGYQEANLVKLGVSINGKHIDEFSLITPSSQATAKAKTLVSKLKMEIPRQQYDVNIKATVGNSTKAIVQGTIRAYKKDFSQLLKGNFGGGGMERLNKKLSHQKKGKERMKMIGQIQVPKEAFINTMSDFLNGIASLTKTVQDTLNSYEVRKISDKVQNYVMNFTEPEMKVREATSEEAWGPTPDMMREIAGLTFQYDAFPEVMGMLWKRMLPPSPVAWRHTYKSLLLLEYLLKNGCERVIASARDHAFEMRSLERYKCTDERGRDQGVNEDDELLRQERLKAKSASRDDKYRGYSRDDMVMRGGSNFSSSSKNYRSNRYDDEDCRNDGRYDRDDRFDDEKSNKREVTSFGFDDEKRSASPELGIRLDSPHKDNDEDDEFGDFTVARSNINNAAKTAGNNKDSFDFGGFASSLPPPPTSTTSKPAASNKIIDDDLFGFSNAATAEKKKDEFDFLGLGSDSQPTSSIRPPSGPSSPTLGGDLFGAPSNSKPTDDFLFGAPSNSSKVSDDLFGISAPAKSVQDSSFDFLGLSSPSPGAQPFPSQTPQSKSDDFLNSLQSVPPQTKSPDTKGTAGAQNNQANKSALWNDLSGSLDLDNLLSTKPKQSMSMNEMKSRQGMTSCKEMRIRIFEFFVLLFFGLNNSLILANELFDKSIPDEETHLTDMDFLAARTFTDPGMFHGKVNDSAMYRKDRFEGDIVNSGLNGRTMKHFLEENGLGKIPGIMRNAVKQTYLMWTDGRIPYTISSQYSSFSRSKIAEAIEEYRRLTCIDFAPKSAADQDYIHIVPDDGCYSLVGRIGGKQPVSLGDGCIQKGIIIHELMHAVGFFHEQSRADRDDYVTINWNNVEAGLQDQFDKYSLNMIDHLDTTYDYGSVMHYASTAFSKNGKPTIEPKKKGVEIGQRTGFSETDIYKINKLYKCSQFVSTTASPEDTLSEVLKPGNKTTDSSTDKGSGENPHEEIENISGGVVSGGSGKGSGHCRDRRRDCEFLSRSGHCESRFSKKFMAENCPKSCHKCKSTCEDTRSWCERWANSGMCTQSIFKEYMKQKCAKSCQLC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias767-802Basic and acidic residues
Compositional bias820-884Basic and acidic residues
Compositional bias961-976Polar residues
Compositional bias1433-1450Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VOSG01000006
EMBL· GenBank· DDBJ
KAE9556216.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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