A0A6G0UJH0 · A0A6G0UJH0_9BILA
- ProteinAlpha-1,3/1,6-mannosyltransferase ALG2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids715 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.
Catalytic activity
- a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
a β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19511 + CHEBI:57527 = an α-D-Man-(1→3)-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19513 + CHEBI:58189 + CHEBI:15378 - an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-1,3/1,6-mannosyltransferase ALG2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Panagrolaimomorpha > Panagrolaimoidea > Panagrolaimidae > Halicephalobus
Accessions
- Primary accessionA0A6G0UJH0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 5-25 | Helical | |||
Transmembrane | 31-55 | Helical | |||
Transmembrane | 75-98 | Helical | |||
Transmembrane | 139-166 | Helical | |||
Transmembrane | 187-211 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 242-410 | Glycosyltransferase subfamily 4-like N-terminal | |||
Domain | 422-580 | Glycosyl transferase family 1 | |||
Region | 654-673 | Disordered | |||
Sequence similarities
Belongs to the glycosyltransferase group 1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length715
- Mass (Da)81,158
- Last updated2020-08-12 v1
- Checksum269087F664B0F4AC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VOSG01000414 EMBL· GenBank· DDBJ | KAE9549271.1 EMBL· GenBank· DDBJ | Genomic DNA |