A0A6G0ISC4 · A0A6G0ISC4_LARCR

Function

function

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncarbohydrate binding
Molecular Functionmetal ion binding
Biological Processcell adhesion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    p-selectin
  • Alternative names
    • CD62 antigen-like family member P
    • Granule membrane protein 140
    • Leukocyte-endothelial cell adhesion molecule 3
    • Platelet activation dependent granule-external membrane protein

Gene names

    • ORF names
      D5F01_LYC07187

Organism names

Accessions

  • Primary accession
    A0A6G0ISC4

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-31
ChainPRO_502600473732-306p-selectin
Disulfide bond158↔168
Disulfide bond179↔188
Disulfide bond226↔253

Keywords

Interaction

Subunit

Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG. Interacts (via C-type lectin domain) with alpha-IIb/beta3 integrin ITGA2B:ITGB3 and alpha-V/beta-3 integrin ITGAV:ITGB3. Interacts with alpha5/beta1 integrin ITGA5:ITGB1 and alpha4/beta1 integrin ITGA4:ITGB.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-154C-type lectin
Domain154-189EGF-like
Domain192-255Sushi

Sequence similarities

Belongs to the selectin/LECAM family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    306
  • Mass (Da)
    35,500
  • Last updated
    2020-08-12 v1
  • Checksum
    02288A98E79D9D41
MKFGVFHTHGSSWTSFIFSSLMLCMWTSVESWSYYYSDKKMVWDEARDWCRENYTDMVAIQNKGEIRHLIKWLPKKDTYYWIGIRKINDTWTWVGTNKALTVEATNWARGEPNNQNKHLKGGAGEDCVEMYIQNRYAGRWNDERCTKLKYALCYTAACKNDSCHHGECVETINSHKCDCFTGFYGEKCEQVVKCNKEEVTTPDKGSVNCTHQYGDFSYDSSCQYSCEEGYQLNMSRPLTCTGTAKWSEQPPTCEPVQCQELSRPERRIHKVFRSPWPIQLPVHLGPVPCSPGAREWLLPAVEMMQT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
REGW02000007
EMBL· GenBank· DDBJ
KAE8294237.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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