A0A6F8PYU7 · A0A6F8PYU7_9VIRU

Function

function

RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.

Catalytic activity

Features

Showing features for active site.

121662004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Active site1091For protease activity
Active site1174For protease activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionmRNA methyltransferase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological Process7-methylguanosine mRNA capping
Biological ProcessDNA-templated transcription
Biological ProcessmRNA modification
Biological Processproteolysis
Biological ProcessRNA methylation
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural replication polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • 17CxNGK-Cps2-1535
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Tymovirales > Tymoviridae > Tymovirus

Accessions

  • Primary accession
    A0A6F8PYU7

Subcellular Location

Host endomembrane system
; Peripheral membrane protein
Host nucleus

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain57-218Alphavirus-like MT
Region532-568Disordered
Compositional bias545-568Polar residues
Region602-641Disordered
Compositional bias605-641Polar residues
Region655-683Disordered
Region982-1020Disordered
Compositional bias991-1008Pro residues
Domain1232-1542+RNA virus helicase C-terminal
Domain1901-2007RdRp catalytic

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,166
  • Mass (Da)
    243,818
  • Last updated
    2020-08-12 v1
  • Checksum
    73C222C7ACD85B43
MFGTLSTTLASTVHRDAITHPLAERAVPAHRDALERYPYNLSDWGLRYAMHHGIMVPGTGFTAHPHPVHKTFEKYLLHEYWSCLARTPSTVMYMKRQKFERLRAQNPNFTHLFNQIHTNRDEQRYECTNNGPITTELAFMHDALMYVSMSSILDLFERSPRLQTLYASLVIPAESSIHASSMTPDLYRYSIRGTELIYQLEGSEDGAYTQPLKALDWLKCHEIVGPRFSLSVSLCSTKGPFHVLQIARTEASKEYRRFYTPSSYVLPVDTAKNIEPVGNRLVPSQVYESLFTYVRAVRTLRVTDVAGYVRTQQTKPEYNWVSPAAWDRLNQFVLQTSHYRPNHVFRLFSSLWDQLLCWLEPRAYIAQSGACLLTGSLLGAAFKWSDKNRISLFRLRSHNFVNDSINPFTMYWRKMPRWITGQAANLIKTEKKFEPIDWMKQQIPSAIIKRFPQYAPRTHWKHYAAATAVGLGFAAAIWYATRDYTQNCKVTQYYNYMHPKRFYLEWETESFNVPEHEPFFLLPFLETESGPRPDVLPPLAVQPTPSQPGTATSSSQADEDDDQPPSWLTRTLESLSPFALDRSRRATQATNTTPAEDLEMQELGEEQTQAPSAQANAPTAVAHPNLSPQPIGGSPTANTIQSPQTVDNAAAHAISTANGPPAANNSGSAPPQQLPSSGTNSAVPSSTIDFLAAADRQEIEITRAQPDLVQPTASAPVSPDNFRRYLVPFFDRVRALPSQQTDEFRNLRYRQTLKLFSLLTFIAFNPAHSPRILELGAGPGTWTRALYRITHGHRQELVAVTPSNGFPFDNILVRAAAQDETLTLVDSTFERYLSETHAPYQLVISDVAQEDTYLDNGTQRRLINLILGSRGPVFTPGATFICKVSNCFLDDLPPMLDRLRSSFRRVSLLKPRGSRLRSTEAYIVAQGFGTSGSGPDPPNNQPTIIDAIFTRCQQLLAGESPEDTEAGRAFDAFVQRYAAPTETTPASTLGNPPSAPSPIPPRPPTTPATLTPAAADESGDFQPAHFDQQAVNPAPPTDDMVAESLLAADPTAVGPVVLARALYNMSEVGGLWNTRRRRADAPIPPIISGRCLLTALSRSLSVSVQVLWERLAMNLPDSQLRGPAELRMGLTFDHLEVLASLFNFRAIVNLVDHNTFTGPPTANREVYLSYRPGHWEYLAERPPGPLHSPLSEEAMRGADSSPNHLYRFLKQHTDIPTRAVHCYPLHLHRAKNLMSNMKNHLEGAMFRTTDRPNTSPDHLHMLSAVVDSCGPRSVDLSVVLGFPGCGKSYPIMQALKVRKKRDFMVIVPTVNLRNEWLTALQLPSNENWRVSTWEVALTRTVDFVIIDEIFKLPNGYLDLLIALNPNLHSALVLGDPLQGDYHSVNEDSTNRFITSELYHLQPFFTSYIAYTRRLDNYTAGCLGVRTYSNRFYAATRGQRLNSKKTTLVTQRAIASNMNMNGIPSYTAAGSQGLTVNDRVTIVIDKSWNRCSPQISFVACTRSRSGVHFAGLQPGEYPLAAGAHPAFEALLTGKTIDYVRHFQDLLGNSIIIRTEKQMKKLGHHHIVRRGAGDHFRSLNNRYHRMTQFKFDPYHPRAIRDPYGPQVKSTYTGDVLLDYNVPCLDTQIIPSLDTNHLPETRRPLHYDINCAAPEPLSISEVELPSAPIEPVYPGYNYEVLIPELTREEDPQDLEIWHKGERSNQFPFLNLEFRIGAQTFSILAPFHNSKKDHTLLSASIEKRLRFRTSDAPTIPTARDHHAAQLLYMSYCEALDIDPDATVPFDSELFLDCILENEFAQLSSKSQAVIMANAERSDPDWRYSYVRIFSKTQHKINNDSLFTGWKACQTLALFHDYLVLVFGPVKKYQRAILERQGKNKNVFIYAGHSPFDLSAYVRANFPPNTHRAWNDFSAFDQSQGVETTLFEVKKMERVCIPAPLVEEHLRIKTRLTCQFGPLTSMRFTGEPGTYDDNTDYNIAITNLRYFIRETPCLFSGDDSAMAKRLPERDTWKANSEFFSNLRFKAESGQYATFCGYYIGSEGAVRCPKPLITKLMLALDEDALDDKLASYVTEFSVGHSLGDEMWNLLPLDQVPYQSAAFDFICRHAPRELKVALNIGSVPADVLSTWTGTITRPLFALLSKAQRLAYLKSFPSRFASWAHSFLPSREGL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias545-568Polar residues
Compositional bias605-641Polar residues
Compositional bias991-1008Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC512732
EMBL· GenBank· DDBJ
BBQ04465.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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