A0A6F8PYU7 · A0A6F8PYU7_9VIRU
- ProteinNon-structural replication polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2166 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
RNA-directed RNA polymerase is responsible for the replication and transcription of the genome.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1091 | For protease activity | ||||
Sequence: C | ||||||
Active site | 1174 | For protease activity | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | mRNA methyltransferase activity | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | 7-methylguanosine mRNA capping | |
Biological Process | DNA-templated transcription | |
Biological Process | mRNA modification | |
Biological Process | proteolysis | |
Biological Process | RNA methylation | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNon-structural replication polyprotein
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Tymovirales > Tymoviridae > Tymovirus
Accessions
- Primary accessionA0A6F8PYU7
Subcellular Location
UniProt Annotation
GO Annotation
Host endomembrane system ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 57-218 | Alphavirus-like MT | ||||
Sequence: PGTGFTAHPHPVHKTFEKYLLHEYWSCLARTPSTVMYMKRQKFERLRAQNPNFTHLFNQIHTNRDEQRYECTNNGPITTELAFMHDALMYVSMSSILDLFERSPRLQTLYASLVIPAESSIHASSMTPDLYRYSIRGTELIYQLEGSEDGAYTQPLKALDWL | ||||||
Region | 532-568 | Disordered | ||||
Sequence: RPDVLPPLAVQPTPSQPGTATSSSQADEDDDQPPSWL | ||||||
Compositional bias | 545-568 | Polar residues | ||||
Sequence: PSQPGTATSSSQADEDDDQPPSWL | ||||||
Region | 602-641 | Disordered | ||||
Sequence: ELGEEQTQAPSAQANAPTAVAHPNLSPQPIGGSPTANTIQ | ||||||
Compositional bias | 605-641 | Polar residues | ||||
Sequence: EEQTQAPSAQANAPTAVAHPNLSPQPIGGSPTANTIQ | ||||||
Region | 655-683 | Disordered | ||||
Sequence: STANGPPAANNSGSAPPQQLPSSGTNSAV | ||||||
Region | 982-1020 | Disordered | ||||
Sequence: ETTPASTLGNPPSAPSPIPPRPPTTPATLTPAAADESGD | ||||||
Compositional bias | 991-1008 | Pro residues | ||||
Sequence: NPPSAPSPIPPRPPTTPA | ||||||
Domain | 1232-1542 | +RNA virus helicase C-terminal | ||||
Sequence: NLMSNMKNHLEGAMFRTTDRPNTSPDHLHMLSAVVDSCGPRSVDLSVVLGFPGCGKSYPIMQALKVRKKRDFMVIVPTVNLRNEWLTALQLPSNENWRVSTWEVALTRTVDFVIIDEIFKLPNGYLDLLIALNPNLHSALVLGDPLQGDYHSVNEDSTNRFITSELYHLQPFFTSYIAYTRRLDNYTAGCLGVRTYSNRFYAATRGQRLNSKKTTLVTQRAIASNMNMNGIPSYTAAGSQGLTVNDRVTIVIDKSWNRCSPQISFVACTRSRSGVHFAGLQPGEYPLAAGAHPAFEALLTGKTIDYVRHFQ | ||||||
Domain | 1901-2007 | RdRp catalytic | ||||
Sequence: THRAWNDFSAFDQSQGVETTLFEVKKMERVCIPAPLVEEHLRIKTRLTCQFGPLTSMRFTGEPGTYDDNTDYNIAITNLRYFIRETPCLFSGDDSAMAKRLPERDTW |
Sequence similarities
Belongs to the Tymoviridae non-structural replication polyprotein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,166
- Mass (Da)243,818
- Last updated2020-08-12 v1
- Checksum73C222C7ACD85B43
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 545-568 | Polar residues | ||||
Sequence: PSQPGTATSSSQADEDDDQPPSWL | ||||||
Compositional bias | 605-641 | Polar residues | ||||
Sequence: EEQTQAPSAQANAPTAVAHPNLSPQPIGGSPTANTIQ | ||||||
Compositional bias | 991-1008 | Pro residues | ||||
Sequence: NPPSAPSPIPPRPPTTPA |