A0A6D2XIL2 · A0A6D2XIL2_PANTR
- ProteinPhospholipase A2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids138 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 49 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 51 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 67 | ||||
Binding site | 68 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 111 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-independent phospholipase A2 activity | |
Biological Process | arachidonic acid secretion | |
Biological Process | cardiolipin acyl-chain remodeling | |
Biological Process | leukotriene biosynthetic process | |
Biological Process | phosphatidylcholine catabolic process | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | positive regulation of immune complex clearance by monocytes and macrophages | |
Biological Process | positive regulation of phospholipase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipase A2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A6D2XIL2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5025709785 | 21-138 | Phospholipase A2 | ||
Disulfide bond | 48↔64 | ||||
Disulfide bond | 63↔117 | ||||
Disulfide bond | 70↔110 | ||||
Disulfide bond | 79↔103 | ||||
Disulfide bond | 97↔108 | ||||
Keywords
- PTM
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length138
- Mass (Da)15,718
- Last updated2020-06-17 v1
- MD5 Checksum556A622D378E057E531116FCCEAD651C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NBAG03000373 EMBL· GenBank· DDBJ | PNI33508.1 EMBL· GenBank· DDBJ | Genomic DNA |