A0A6D2WPC6 · A0A6D2WPC6_PONAB
- ProteinAldehyde dehydrogenase
- GeneALDH3A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids453 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
Catalytic activity
- octanal + NAD+ + H2O = octanoate + NADH + 2 H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 210 | |||||
Sequence: E | ||||||
Active site | 244 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | plasma membrane | |
Molecular Function | 3-chloroallyl aldehyde dehydrogenase activity | |
Molecular Function | alcohol dehydrogenase (NADP+) activity | |
Molecular Function | benzaldehyde dehydrogenase (NAD+) activity | |
Biological Process | cellular aldehyde metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAldehyde dehydrogenase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pongo
Accessions
- Primary accessionA0A6D2WPC6
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-425 | Aldehyde dehydrogenase | ||||
Sequence: KISEAVKRARAAFSSGRTRPLQFRIQQLEALRRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYMLCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPLLPIVCVRSLEEAIQFINQREKPLALYVFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHR | ||||||
Coiled coil | 23-50 | |||||
Sequence: LQFRIQQLEALRRLIQEQEQELVGALAA |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length453
- Mass (Da)50,479
- Last updated2020-06-17 v1
- Checksum30B5078E6DA157DD
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2J8RC43 | A0A2J8RC43_PONAB | ALDH3A1 | 389 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NDHI03003712 EMBL· GenBank· DDBJ | PNJ06096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDHI03003712 EMBL· GenBank· DDBJ | PNJ06097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDHI03003712 EMBL· GenBank· DDBJ | PNJ06101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDHI03003712 EMBL· GenBank· DDBJ | PNJ06103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDHI03003712 EMBL· GenBank· DDBJ | PNJ06104.1 EMBL· GenBank· DDBJ | Genomic DNA |