A0A6C7HNI2 · A0A6C7HNI2_SALEP

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1784100200300400500600700
TypeIDPosition(s)Description
Binding site356-363ATP (UniProtKB | ChEBI)
Active site679
Active site722

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease
  • EC number
  • Alternative names
    • ATP-dependent protease La

Gene names

    • Name
      lon
    • ORF names
      G2359_06185
      , G2427_04285
      , G2691_04285
      , G2712_04050
      , G2720_07590
      , G2854_03620
    • Ordered locus names
      SEN0432

Organism names

Accessions

  • Primary accession
    A0A6C7HNI2

Proteomes

Subcellular Location

Keywords

Expression

Induction

By heat shock.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain11-204Lon N-terminal
Coiled coil190-227
Domain592-773Lon proteolytic

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    784
  • Mass (Da)
    87,411
  • Last updated
    2020-06-17 v1
  • Checksum
    A93DE549483D959A
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYIRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM933172
EMBL· GenBank· DDBJ
CAR32018.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQLS010000002
EMBL· GenBank· DDBJ
HAD9859299.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQOY010000002
EMBL· GenBank· DDBJ
HAE0255438.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQPD010000002
EMBL· GenBank· DDBJ
HAE0278961.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQPM010000002
EMBL· GenBank· DDBJ
HAE0329086.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQRD010000004
EMBL· GenBank· DDBJ
HAE0517755.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQSA010000002
EMBL· GenBank· DDBJ
HAE0636672.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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