A0A6C7HNI2 · A0A6C7HNI2_SALEP
- ProteinLon protease
- Genelon
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids784 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalytic activity
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | cellular response to heat | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLon protease
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A6C7HNI2
Proteomes
Subcellular Location
Expression
Induction
By heat shock.
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity.
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-204 | Lon N-terminal | ||||
Sequence: IPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI | ||||||
Coiled coil | 190-227 | |||||
Sequence: NERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQRE | ||||||
Domain | 592-773 | Lon proteolytic | ||||
Sequence: ENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQN |
Sequence similarities
Belongs to the peptidase S16 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length784
- Mass (Da)87,411
- Last updated2020-06-17 v1
- ChecksumA93DE549483D959A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM933172 EMBL· GenBank· DDBJ | CAR32018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQLS010000002 EMBL· GenBank· DDBJ | HAD9859299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQOY010000002 EMBL· GenBank· DDBJ | HAE0255438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQPD010000002 EMBL· GenBank· DDBJ | HAE0278961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQPM010000002 EMBL· GenBank· DDBJ | HAE0329086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQRD010000004 EMBL· GenBank· DDBJ | HAE0517755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQSA010000002 EMBL· GenBank· DDBJ | HAE0636672.1 EMBL· GenBank· DDBJ | Genomic DNA |