A0A6C0WW05 · A0A6C0WW05_ACISI

Function

function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionnuclear receptor activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processfatty acid metabolic process
Biological Processhormone-mediated signaling pathway
Biological Processnegative regulation of cholesterol storage
Biological Processnegative regulation of inflammatory response
Biological Processpositive regulation of fatty acid metabolic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisome proliferator-activated receptor gamma
  • Short names
    PPAR-gamma
  • Alternative names
    • Nuclear receptor subfamily 1 group C member 3

Gene names

    • Name
      PPARgamma
    • Synonyms
      PPARG

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Acipenseridae > Acipenser

Accessions

  • Primary accession
    A0A6C0WW05

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer with other nuclear receptors.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain108-182Nuclear receptor
Domain247-478NR LBD

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    55,097
  • Last updated
    2020-06-17 v1
  • Checksum
    003775711B68D044
MVDTQLPMWQVSFGLNPVDMAELDDHSHSFDIKPYTTVDYSGISNRPYDYSPPERSNLTELDCKYDFKLQQYHHTSTIKLEPPSPPQYSDKSFPYTKLHEDPLNSTLSVECRVCADKASGFHYGVHACEGCKGFFRRTIRLKLVYDRCDLNCRIHKKSRNKCQYCRFQKCLMVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQMNPESADLRALAKHLYDSYFKSFPLTKSKARAILTGKTGDKAPFVIHDMNSLKAGEHYISFKQPPVPEQGQQQNKDMEIRLFQSCQFRSVEAVREITEFAKSIPGFVNLDLNDQVTLLKYGVHEVIFSMLASLMNKDGALVSCGQGFMTREFLKSLRKPFCELLEPKFDFSVKFNALELDDSDLAVFISVIILSGDRPGLVNVKPIEDLQDNMLQALELQLKMNHPDSPQLFAKLLQKMTDLRQIVTEHVQLLQLLKKTELDMDIHPLLQEIIKDLY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK474627
EMBL· GenBank· DDBJ
QIC50195.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp