A0A6B9MFN5 · A0A6B9MFN5_9PASE

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Motacillidae > Motacilla

Accessions

  • Primary accession
    A0A6B9MFN5

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-28Helical
Transmembrane40-58Helical
Transmembrane86-107Helical
Transmembrane119-136Helical
Transmembrane142-161Helical
Transmembrane173-192Helical
Transmembrane212-234Helical
Transmembrane246-268Helical
Transmembrane274-295Helical
Transmembrane302-322Helical
Transmembrane334-352Helical
Transmembrane373-392Helical
Transmembrane404-425Helical
Transmembrane455-474Helical
Transmembrane486-506Helical
Transmembrane585-603Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain70-120NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain136-417NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain423-603NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    66,366
  • Last updated
    2020-06-17 v1
  • Checksum
    153171475CCE810C
MDLSLVLNTFMLLTLATLFTPILFPLLSNNLKNTPTTITNTVKTSFLISLIPMTIYIHSGTESLTTVWEWKYIMNFKIPVSLKMDFYSLTFFPIALFVSWSILQFATWYMASDPYITKFFTYLLFFLIAMLILIIANNLFVLFIGWEGVGIMSFLLISWWYGRAEANTAALQAVLYNRVGDIGLILCMAWLASTMNTWEIHQLSSPNQTPTLPLLGLILAATGKSAQFGLHPWLPAAMEGPTPVSALLHSSTMVVAGIFLLIRTYPLFHNNQTALTLCLCLGALSTLFAATCALTQNDIKKIIAFSTSSQLGLMMVTIGLNLPELAFLHISTHAFFKAMLFLCSGSIIHSLNGEQDIRKMGGLQKMLPTTTSCLTIGNLALMGTPFLAGFYSKDQIIESLSTSYLNAWALLLTLLATSFTAVYTIRMTVLVQTGFVRIPPLTPMNENNPAVTSPITRLALGSIMAGFLITSFIIPTKTPPMTMPLSIKMTALAVTALGIALALEISKMAQTLILTKQTTLSNFSVSLGYFNPLAHRLSMTKILSGGQNIASHLIDLSWYKMFGPEGLANLQQTAAKTATTLHTGLIKAYLGAFALSILIMLMSTY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN217252
EMBL· GenBank· DDBJ
QHB79337.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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