A0A6B9KLW0 · A0A6B9KLW0_9POTV

Function

function

Has helicase activity. It may be involved in replication.
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.

Catalytic activity

  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
    EC:3.4.22.45 (UniProtKB | ENZYME | Rhea)
  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
    EC:3.4.22.44 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

132805001,0001,5002,0002,5003,000
TypeIDPosition(s)Description
Active site874For helper component proteinase activity
Active site947For helper component proteinase activity

GO annotations

AspectTerm
Cellular Componenthelical viral capsid
Cellular Componenthost cell cytoplasmic vesicle
Cellular Componenthost cell nucleus
Cellular Componentvesicle
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type peptidase activity
Molecular Functionstructural molecule activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PRSV.PC-OS
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus

Accessions

  • Primary accession
    A0A6B9KLW0

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil278-312
Domain392-531Peptidase S30
Domain866-988Peptidase C6
Domain1457-1609Helicase ATP-binding
Domain1628-1787Helicase C-terminal
Region2243-2266Disordered
Compositional bias2246-2266Polar residues
Domain2267-2483Peptidase C4
Domain2745-2869RdRp catalytic
Compositional bias3057-3077Basic and acidic residues
Region3057-3097Disordered

Sequence similarities

Belongs to the potyviridae genome polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,280
  • Mass (Da)
    373,682
  • Last updated
    2020-06-17 v1
  • Checksum
    20D7B9D6F578525F
MESKKGFGLIERKLEWKGDAGNTHYCSEFHISKGAKILQLVQIGDAEIGRAFLEGNKFIRANIFEIIRKTMVGRLGYDFDSELWVCHNCDKTSGKYFKKCDCGEKYYYSERNLIRTMQDLMYQFDMTPSEIDSIDFDYLADAVEYAEQSVKRSQVPEPVELAIMETIATSEEGVLMSSGSEVVPTTTKVEEAWTIQIGEIPVPLVVFKETPVVNGVNRTLNSTDFPLEAGITKLIEKENLQKDVKEVVHLALEVGNEIAKRKPELKLMPYWSASLELHKRIRKHKEHAKEAAKQIQKEREKHQKIFSDLESRLNLKSRRRNQTVVCDKRGTLKWKTRQGYKKNRLVQQVSDSVLTQIHCDFSCEPQRFEPHLPGIKQATSKKFRKSRKQPRIVGNNKINYVMKNLCNTIVERSIPVELVTKRCKRRILQKDGRSYVQLRHMDGIRTQRDVCSSRDMEQLFTQFCKFLVGHKPLKSGNLTFGSSGLIFKPKFGDNVGRYFGDYFIVRGRLNGRLFDGRSKLAKSIYGKMEQYNDVAEKFWLGFNRAFLRHRKPTDHTCTSDMDVTMCGEVAALATIILFPCHKITCNTCMSKVKGRVIDEVGEDLNCELERLRETLSSYGGSFGHVSTLLDQLNRVLNARNTNDGVFKEIAKKIDAKKESPWTHMTAINNTLIKGSLATGYEFERASDSLLEIVRWHLKRTESIKAGSVESFRNKRSGKAHFNPALACDNQLDRNGNFLWGERQYHAKRFFANYFEKIDHSKGYEYYSQRQNPNGIRRIAIGNLVFSTNLERFRQQMVEHHIDQGPITRECIALRNNNYVHVCSCVTLDDGTPATSELKTPTKNHIVLGNSGDPKYVDLPVLESDSMYIAKKGYCYMNIFLAMLVNIPENEAKDFTKRVRDLVGSKLGEWPTMLDVATCANQLIIFHPDAASAELPRILVDHRQKTMHVIDSFGSIDSGYHILKANTVNQLIQFARDPLDSEMKHYIVGGEFDSTTNCLHQLIRVIYKPHELRNLLRNEPYLIVIALMSPSVLLTLFNSGAIEHALNYWIKRDQDVVEVIVLVEQLCRKVTLARTILEQFNEIRQNARDIHELMDRNNKPWISYDRSLELLSVYANSQLTDEGLLKQGFSTLDPRLREAVEKTYATLLQEEWRALSLFQKLHLRYFAYKSQPSFSEYLKPRGRADLKVVYDFSPKYCVHEVGKALLQPVKVGAEITSRIINGCGTFIRKSAARGCAYIFKDLFQFVHVVLVLSILLQIFRSAQGIATEHIQLKQAKAEVEKQKNFDRLEALYAELCVKSGEQPTAEEFLDFVVEREPSLKDQAYSLIYIPVVHQAKSDNEKKLEQVIAFITLILMMIDVDKSDCVYRILNKFKGVMKSCDTNVYHQSLDDIRDFYEDKQLTIDFDITGENQINRGPIDVTFEKWWDNQLSNNNTIGHYRIGGTFVEFSRSNAATVASEIAHSPDREFLVRGAVGSGKSTNLPFLLSKHGSVLLIEPTRPLCENVCKQLRGEPFHCNPTIRMRGLTAFGSTNITIMTSGFALHYYAHNIQQLRLFDFVIFDECHAIDSQAMAFYCLMEGNAIEKKILKVSATPPGREVEFSTQFPTKIVTEQSISFKQLVDNFGTGANSDVTAFADNILVYVASYNEVDQLSKLLSDKGYLVTKIDGRTMKVGKTEISTSGTKSKKHFIVATNIIENGVTLDIEAVIDFGTKVVPEMDSDNRMIRYSKQAISFGERIQRLGRVGRHKEGIALRIGHTEKGIQEIPEMAATEAAFLSFTYGLPVMTHNVGLSLLKNCTVRQARTMQQYELSPFFTQNLVNFDGTVHPKIDVLLRPYKLRDCEVRLSEAAIPHGVQSIWMSAREYEAVGGRLCLEGDIRIPFLIKDVPERLYRELWDIVQTYKRDFTFGRINSVSAGKIAYTLRTDVYSIPRTLITIDKLIESENMKHAHFKAMTSCTGLNSSFSLLGVINTIQSRYLVDHSVENIRKLQLAKAQIQQLETHAQENNVENLIQSLGAVRAVYHQGVDGVKHIKRELGLRGIWDGSLMIKDAIVCGFTMAGGAMLLYQHFRDKLTNVHVFHQGFSARQRQKLRFKSAANAKLGREVYGDDGTIEHYFGEAYTKKGNKKGKMHGMGVKTRKFVATYGFKPEDYSYVRYLDPLTGETLDESPQTDISMVQEHFGEIRRKYMDSDSFDKQVLIANNTIKAYYVRNSAKTALEVDLTPHNPLKVCDNKLTIAGFPDREAELRQTGPPRTIQSDQVPPSSKSVHHEGKSLCQGMRNYNGIASVVCHLKNTSGKGKSLFGIGYSSFIITNRHLFKENNGELIVKSQHGKFVVKNTTTLQLAPIGKTDLLIIRMPKDFPPFHSRARFRAMKAGDKVCMIGVDYQENHIASKVSETSIISEGMGDFGCHWISTNDGDCGSPLVSVSDGFIVGLHSLSTSTGDQNFFAKIPAQFEENILRKIDGLIWSKHWSYNTNELSWGALKVWESRPEAIFNAQKEVNQLNVFEQSGSRWLFDKLHGNLKGVSCASSNLVTKHVVKGICPLFRNYLECDEEAKIFFSPLMGHYMKSVLSKEAYIKDLLKYSSDIVVGEVNHDIFEDSVAQVLELLNDHECPEFEYITDGEVIIQALNMDAAVGALYTGKKRKYFEGSTVEHRQALVRKSCERLYEGRMGVWNGSLKAELRSAEKVLAKKTRSFTAAPLDTLLGAKVCVDDFNNWFYSKNIECPWTVGMTKFYKGWDEFLKKFPDGWVYCDADGSQFDSSLTPYLLNAVLSIRLWAMEDWDIGEQMLKNLYGEITYTPILTPDGTIVKKFKGNNSGQPSTVVDNTLMVLITMYYALRKAGYDTEAQEDMCVFYINGDDLCIAIHPDHEHVLDSFSSSFAELGLKYDFTQRHRNKQDLWFMSHRGILIDDIYIPKLEPERIVAILEWDKSKLPEHRLEAITAAMIESWGYGELTHQIRRFYQWILEQAPFNELAKQGRAPYVSEVGLRRLYTSERGSMDELEAYIDKYFERERGDSPELLVYHESRITDGSQFICGNYTHVFHQSKNEAVDAGLNEKLKEKEKQKEKEKQKEKERGDASDGNDVSTSTKTGERDRDVNVGTNGTFTVPRIKSFTDKMILPKIKGKTVLNLNHLLQYIENGTSPDISGVWVMMDGETQVDYPIKPLVEHATPSFRQIMAHFSNAAEAYIAKRNATERYMPRYGIKRNLTDISLARYAFDFYEVNSKTPDRAREAHMQMKAAALRNSNRRMFGMDGSVSNKEENTERHTVEDVNRDMHSLLGMRN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias2246-2266Polar residues
Compositional bias3057-3077Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN203184
EMBL· GenBank· DDBJ
QHA79285.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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