A0A6B9KLW0 · A0A6B9KLW0_9POTV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3280 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Has helicase activity. It may be involved in replication.
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Catalytic activity
- Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 874 | For helper component proteinase activity | ||||
Sequence: C | ||||||
Active site | 947 | For helper component proteinase activity | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | helical viral capsid | |
Cellular Component | host cell cytoplasmic vesicle | |
Cellular Component | host cell nucleus | |
Cellular Component | vesicle | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | serine-type peptidase activity | |
Molecular Function | structural molecule activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus
Accessions
- Primary accessionA0A6B9KLW0
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 278-312 | |||||
Sequence: HKRIRKHKEHAKEAAKQIQKEREKHQKIFSDLESR | ||||||
Domain | 392-531 | Peptidase S30 | ||||
Sequence: IVGNNKINYVMKNLCNTIVERSIPVELVTKRCKRRILQKDGRSYVQLRHMDGIRTQRDVCSSRDMEQLFTQFCKFLVGHKPLKSGNLTFGSSGLIFKPKFGDNVGRYFGDYFIVRGRLNGRLFDGRSKLAKSIYGKMEQY | ||||||
Domain | 866-988 | Peptidase C6 | ||||
Sequence: MYIAKKGYCYMNIFLAMLVNIPENEAKDFTKRVRDLVGSKLGEWPTMLDVATCANQLIIFHPDAASAELPRILVDHRQKTMHVIDSFGSIDSGYHILKANTVNQLIQFARDPLDSEMKHYIVG | ||||||
Domain | 1457-1609 | Helicase ATP-binding | ||||
Sequence: EIAHSPDREFLVRGAVGSGKSTNLPFLLSKHGSVLLIEPTRPLCENVCKQLRGEPFHCNPTIRMRGLTAFGSTNITIMTSGFALHYYAHNIQQLRLFDFVIFDECHAIDSQAMAFYCLMEGNAIEKKILKVSATPPGREVEFSTQFPTKIVTE | ||||||
Domain | 1628-1787 | Helicase C-terminal | ||||
Sequence: DVTAFADNILVYVASYNEVDQLSKLLSDKGYLVTKIDGRTMKVGKTEISTSGTKSKKHFIVATNIIENGVTLDIEAVIDFGTKVVPEMDSDNRMIRYSKQAISFGERIQRLGRVGRHKEGIALRIGHTEKGIQEIPEMAATEAAFLSFTYGLPVMTHNVG | ||||||
Region | 2243-2266 | Disordered | ||||
Sequence: RQTGPPRTIQSDQVPPSSKSVHHE | ||||||
Compositional bias | 2246-2266 | Polar residues | ||||
Sequence: GPPRTIQSDQVPPSSKSVHHE | ||||||
Domain | 2267-2483 | Peptidase C4 | ||||
Sequence: GKSLCQGMRNYNGIASVVCHLKNTSGKGKSLFGIGYSSFIITNRHLFKENNGELIVKSQHGKFVVKNTTTLQLAPIGKTDLLIIRMPKDFPPFHSRARFRAMKAGDKVCMIGVDYQENHIASKVSETSIISEGMGDFGCHWISTNDGDCGSPLVSVSDGFIVGLHSLSTSTGDQNFFAKIPAQFEENILRKIDGLIWSKHWSYNTNELSWGALKVWE | ||||||
Domain | 2745-2869 | RdRp catalytic | ||||
Sequence: WVYCDADGSQFDSSLTPYLLNAVLSIRLWAMEDWDIGEQMLKNLYGEITYTPILTPDGTIVKKFKGNNSGQPSTVVDNTLMVLITMYYALRKAGYDTEAQEDMCVFYINGDDLCIAIHPDHEHVL | ||||||
Compositional bias | 3057-3077 | Basic and acidic residues | ||||
Sequence: EKEKQKEKEKQKEKERGDASD | ||||||
Region | 3057-3097 | Disordered | ||||
Sequence: EKEKQKEKEKQKEKERGDASDGNDVSTSTKTGERDRDVNVG |
Sequence similarities
Belongs to the potyviridae genome polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,280
- Mass (Da)373,682
- Last updated2020-06-17 v1
- Checksum20D7B9D6F578525F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2246-2266 | Polar residues | ||||
Sequence: GPPRTIQSDQVPPSSKSVHHE | ||||||
Compositional bias | 3057-3077 | Basic and acidic residues | ||||
Sequence: EKEKQKEKEKQKEKERGDASD |