A0A6B9FDV0 · A0A6B9FDV0_9HYPH

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site19-24substrate
Binding site51Mg2+ (UniProtKB | ChEBI)
Active site80Proton acceptor
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site81substrate
Binding site162-165substrate
Binding site185substrate
Binding site198-199substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      MMSR116_00315

Organism names

Accessions

  • Primary accession
    A0A6B9FDV0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    22,727
  • Last updated
    2020-06-17 v1
  • Checksum
    8F085DC5784192D8
MSPAPRHGRRLTGKVVIATHNAGKLTEMSELLAPFGVEAVSAGELGLPEPDETGTMFAENAFIKAKAAADATGLPAFADDSGLCVDALDCAPGIFSARWAGPTKDFAGAMARIFAELDQRGAQSRRAHFVSALVLAWPDGHTELFEGRVFGDLVAAKGSAGFGYDPIFRPEGHDRTFGEMSADEKHGVDWQKGEGLSHRARAFVELSRACLAPAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP043538
EMBL· GenBank· DDBJ
QGY00536.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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