A0A6B8W766 · A0A6B8W766_9CORY

  • Protein
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    nnr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site289(6S)-NADPHX (UniProtKB | ChEBI)
Binding site342(6S)-NADPHX (UniProtKB | ChEBI)
Binding site395(6S)-NADPHX (UniProtKB | ChEBI)
Binding site435-439AMP (UniProtKB | ChEBI)
Binding site466AMP (UniProtKB | ChEBI)
Binding site467(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNAD(P)HX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnr
    • Synonyms
      nnrD
    • ORF names
      CETAM_12875

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 2019
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium

Accessions

  • Primary accession
    A0A6B8W766

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-219YjeF N-terminal
Domain254-542YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    57,141
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    B990B2CDE09DD77547CA247B47A3B19F
MSLQSHAYPVDLIRVCEQVLLDAQSAPDELMRQAAHAVAVAAGVLVAAPAPTLLRAQATDRRILLLVGAGGNGGDALYAGAELAANHTVEAVLLGRDGRVHERALTAFRTAGGHVIGGLPEDLRPYRLVVDGILGIGGSGGLNQGLGEWLERVREHHHIPVLAVDVPSGVDADTGALSGHHVTADVTVTFGGLRHVHAVSSACGEVLVADIAVRGRALSEELLRRVILEEAGYVMALRAVHPTGREWPAPLHRLSTYSNNEPLEPEAGDDKYSGGVVGLCAGSATYPGAALLTATGAVRATSAMVRYVGDQKFAVVRAVPEVVISDAVADTGRVQAWVVGPGRGTDAAAEAELAGLLARPEPLLIDADALTLLARSAPLRTILRERTASTLLTPHDGEFRRLADALDAGIPDPAADRLGAVRALSDELDCGVLLKGRHTVIALPGTRLGMYAFDAGSSWAATPGSGDVLAGIAGAWLARAAAWLERMPVEPAQRFPTELLSACDAVQVHSTAAWLAAQTPDGPAPTSASRIAEAVPQATARLVHPEFLGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP046453
EMBL· GenBank· DDBJ
QGU05800.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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